A novel biocompatible europium ligand for sensitive time-gated immunodetection

Nima Sayyadi; Russell E. Connally; Andrew Try

doi:10.1039/c5cc06811h

A novel biocompatible europium ligand for sensitive time-gated immunodetection

Nima Sayyadi^*, Russell E. Connally, Andrew Try

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We describe the synthesis of a novel hydrophilic derivative of a tetradentate β-diketone europium ligand that was used to prepare an immunoconjugate probe against Giardia lamblia cysts. We used a Gated Autosynchronous Luminescence Detector (GALD) to obtain high quality delayed luminescence images of cells 30-fold faster than ever previously reported.

Original language	English
Pages (from-to)	1154-1157
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	6
DOIs	https://doi.org/10.1039/c5cc06811h
Publication status	Published - 21 Jan 2016

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title = "A novel biocompatible europium ligand for sensitive time-gated immunodetection",

abstract = "We describe the synthesis of a novel hydrophilic derivative of a tetradentate β-diketone europium ligand that was used to prepare an immunoconjugate probe against Giardia lamblia cysts. We used a Gated Autosynchronous Luminescence Detector (GALD) to obtain high quality delayed luminescence images of cells 30-fold faster than ever previously reported.",

author = "Nima Sayyadi and Connally, {Russell E.} and Andrew Try",

year = "2016",

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doi = "10.1039/c5cc06811h",

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T1 - A novel biocompatible europium ligand for sensitive time-gated immunodetection

AU - Sayyadi, Nima

AU - Connally, Russell E.

AU - Try, Andrew

PY - 2016/1/21

Y1 - 2016/1/21

N2 - We describe the synthesis of a novel hydrophilic derivative of a tetradentate β-diketone europium ligand that was used to prepare an immunoconjugate probe against Giardia lamblia cysts. We used a Gated Autosynchronous Luminescence Detector (GALD) to obtain high quality delayed luminescence images of cells 30-fold faster than ever previously reported.

AB - We describe the synthesis of a novel hydrophilic derivative of a tetradentate β-diketone europium ligand that was used to prepare an immunoconjugate probe against Giardia lamblia cysts. We used a Gated Autosynchronous Luminescence Detector (GALD) to obtain high quality delayed luminescence images of cells 30-fold faster than ever previously reported.

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U2 - 10.1039/c5cc06811h

DO - 10.1039/c5cc06811h

M3 - Article

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AN - SCOPUS:84953790578

SN - 1359-7345

VL - 52

SP - 1154

EP - 1157

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

A novel biocompatible europium ligand for sensitive time-gated immunodetection

Abstract

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