A novel glycoprotein in the olfactory and pituitary systems of larval and adult lampreys

Stacia A. Sower*, Akiyoshi Takaha Shi, Masumi Nozaki, Aubrey Gorbman, John H. Youson, Jean Joss, Hiroshi Kawauchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A novel homodimeric glycoprotein was isolated and characterized from the pituitaries of adult sea lampreys, Petromyzon marinus, modern representatives of the earliest vertebrates. The monomer consists of 121 amino-acid residues in a sequence that has no resemblance to any known pituitary hormone. Whereas this protein is localized in most cells of the rostral pars distalis of adult lampreys, we have chosen to name it, nasohypophysial factor (NHF), because it first appears in the olfactory system of developing larval lampreys. Not only may NHF be a new pituitary hormone but a useful probe for examining the ontogenetic and phylogenetic relationships of the pituitary and olfactory systems in vertebrates.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalEndocrinology
Volume136
Issue number1
DOIs
Publication statusPublished - 1995

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