A novel microfluidic patterning device for neuron-glia co-culture

A. Shi, J. Shemesh, M. Asadnia, U. A. Robles, R. Green, G. H. Yeoh, M. E. Warkiani*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

Many biological processes in the body are regulated by synchronized activity between two cell types. To study cell-cell interactions, it is necessary to develop easy to use co-culture systems, where different cell types can be cultured within the same confined space. Designing a complete 3D biomimetic system to study these interactions in vitro requires complex protocols and use of non-conventional materials such as hydrogels. This paper reports development of a temporarily sealed microfluidic device which utilizes a novel valve design to directly and accurately co-culture two cell lines in alternating rows, allowing them to proliferate towards each other and then observe their interaction at the boundaries of their interface.

Original languageEnglish
Title of host publication19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)
Place of PublicationGyeongju, South Korea
PublisherChemical and Biological Microsystems Society
Pages633-635
Number of pages3
ISBN (Electronic)9780979806483
ISBN (Print)9781510817876
Publication statusPublished - 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: 25 Oct 201529 Oct 2015

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period25/10/1529/10/15

Keywords

  • Co-culture
  • Microfluidics
  • Neurons

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