A pilot study providing evidence for a relationship between a composite lifestyle score and risk of higher carotid intima-media thickness: is there a link to oxidative stress?

Neda Seyedsadjadi, Jade Berg, Ayse A. Bilgin, Ross Grant

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    Lifestyle behaviours have been closely linked to the progressive cell damage associated with oxidative stress (OS) and the development of cardiovascular disease (CVD). Early detection of lifestyle-linked OS may therefore be useful in the early identification of prodromal disease. To test this hypothesis, this study assessed the relationship between a comprehensive redox balance lifestyle score (RBLS) and carotid intima-media thickness (CIMT), a recognized marker for CVD, and plasma biomarkers of OS. In a cross-sectional study design, 100 apparently healthy middle-aged participants were asked to complete a comprehensive lifestyle questionnaire, followed by DXA scanning, CIMT ultrasonography, and blood collection. The RBLS was composed of lifestyle components with pro- and antioxidant properties with a higher score indicative of lower oxidative activity. Multiple linear regression and logistic regression analysis were performed for statistical analysis. The RBLS was significantly associated with the risk for increased CIMT that was independent of conventional CVD risk factors (χ2(9) = 35.60, P ≤ 0.001). The adjusted model explained 42.4% of the variance in CIMT. Participants with RBLS below the median were at significantly increased risk of higher CIMT compared to participants with RBLS above the median (OR = 3.60, 95% CI: 1.19-10.88, P = 0.023). Significant associations were also observed between the RBLS, plasma total antioxidant capacity (TAC) (r(99) = 0.28, P = 0.006), hydroperoxide (HPX) (rs(99) = -0.28, P = 0.005), TAC/HPX ratio (r(98) = 0.41, P ≤ 0.001), γ-glutamyltransferase (r(97) = -0.23, P = 0.024), uric acid (r(98) = -0.20, P = 0.045), and inflammatory C-reactive protein (rs(97) = -0.25, P = 0.012) and interleukin-1β (r(97) = -0.21, P = 0.040). These findings highlight the importance of identifying the collective influence of lifestyle behaviours on OS activity and its potential to remodel the vascular endothelium.

    LanguageEnglish
    Article number4504079
    Pages1-11
    Number of pages11
    JournalOxidative Medicine and Cellular Longevity
    Volume2018
    DOIs
    Publication statusPublished - 1 Jan 2018

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    Carotid Intima-Media Thickness
    Oxidative stress
    Life Style
    Oxidative Stress
    Composite materials
    Oxidation-Reduction
    Antioxidants
    Hydrogen Peroxide
    Ultrasonography
    Plasmas
    Cardiovascular Diseases
    gamma-Glutamyltransferase
    Biomarkers
    Uric Acid
    Interleukin-1beta
    Linear regression
    Regression analysis
    C-Reactive Protein
    Logistics
    Statistical methods

    Bibliographical note

    Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher

    Cite this

    @article{b0819b41722b4eaba5d1a983bc8a7a83,
    title = "A pilot study providing evidence for a relationship between a composite lifestyle score and risk of higher carotid intima-media thickness: is there a link to oxidative stress?",
    abstract = "Lifestyle behaviours have been closely linked to the progressive cell damage associated with oxidative stress (OS) and the development of cardiovascular disease (CVD). Early detection of lifestyle-linked OS may therefore be useful in the early identification of prodromal disease. To test this hypothesis, this study assessed the relationship between a comprehensive redox balance lifestyle score (RBLS) and carotid intima-media thickness (CIMT), a recognized marker for CVD, and plasma biomarkers of OS. In a cross-sectional study design, 100 apparently healthy middle-aged participants were asked to complete a comprehensive lifestyle questionnaire, followed by DXA scanning, CIMT ultrasonography, and blood collection. The RBLS was composed of lifestyle components with pro- and antioxidant properties with a higher score indicative of lower oxidative activity. Multiple linear regression and logistic regression analysis were performed for statistical analysis. The RBLS was significantly associated with the risk for increased CIMT that was independent of conventional CVD risk factors (χ2(9) = 35.60, P ≤ 0.001). The adjusted model explained 42.4{\%} of the variance in CIMT. Participants with RBLS below the median were at significantly increased risk of higher CIMT compared to participants with RBLS above the median (OR = 3.60, 95{\%} CI: 1.19-10.88, P = 0.023). Significant associations were also observed between the RBLS, plasma total antioxidant capacity (TAC) (r(99) = 0.28, P = 0.006), hydroperoxide (HPX) (rs(99) = -0.28, P = 0.005), TAC/HPX ratio (r(98) = 0.41, P ≤ 0.001), γ-glutamyltransferase (r(97) = -0.23, P = 0.024), uric acid (r(98) = -0.20, P = 0.045), and inflammatory C-reactive protein (rs(97) = -0.25, P = 0.012) and interleukin-1β (r(97) = -0.21, P = 0.040). These findings highlight the importance of identifying the collective influence of lifestyle behaviours on OS activity and its potential to remodel the vascular endothelium.",
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    A pilot study providing evidence for a relationship between a composite lifestyle score and risk of higher carotid intima-media thickness : is there a link to oxidative stress? / Seyedsadjadi, Neda; Berg, Jade; Bilgin, Ayse A.; Grant, Ross.

    In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 4504079, 01.01.2018, p. 1-11.

    Research output: Contribution to journalArticleResearchpeer-review

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    T1 - A pilot study providing evidence for a relationship between a composite lifestyle score and risk of higher carotid intima-media thickness

    T2 - Oxidative Medicine and Cellular Longevity

    AU - Seyedsadjadi, Neda

    AU - Berg, Jade

    AU - Bilgin, Ayse A.

    AU - Grant, Ross

    N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher

    PY - 2018/1/1

    Y1 - 2018/1/1

    N2 - Lifestyle behaviours have been closely linked to the progressive cell damage associated with oxidative stress (OS) and the development of cardiovascular disease (CVD). Early detection of lifestyle-linked OS may therefore be useful in the early identification of prodromal disease. To test this hypothesis, this study assessed the relationship between a comprehensive redox balance lifestyle score (RBLS) and carotid intima-media thickness (CIMT), a recognized marker for CVD, and plasma biomarkers of OS. In a cross-sectional study design, 100 apparently healthy middle-aged participants were asked to complete a comprehensive lifestyle questionnaire, followed by DXA scanning, CIMT ultrasonography, and blood collection. The RBLS was composed of lifestyle components with pro- and antioxidant properties with a higher score indicative of lower oxidative activity. Multiple linear regression and logistic regression analysis were performed for statistical analysis. The RBLS was significantly associated with the risk for increased CIMT that was independent of conventional CVD risk factors (χ2(9) = 35.60, P ≤ 0.001). The adjusted model explained 42.4% of the variance in CIMT. Participants with RBLS below the median were at significantly increased risk of higher CIMT compared to participants with RBLS above the median (OR = 3.60, 95% CI: 1.19-10.88, P = 0.023). Significant associations were also observed between the RBLS, plasma total antioxidant capacity (TAC) (r(99) = 0.28, P = 0.006), hydroperoxide (HPX) (rs(99) = -0.28, P = 0.005), TAC/HPX ratio (r(98) = 0.41, P ≤ 0.001), γ-glutamyltransferase (r(97) = -0.23, P = 0.024), uric acid (r(98) = -0.20, P = 0.045), and inflammatory C-reactive protein (rs(97) = -0.25, P = 0.012) and interleukin-1β (r(97) = -0.21, P = 0.040). These findings highlight the importance of identifying the collective influence of lifestyle behaviours on OS activity and its potential to remodel the vascular endothelium.

    AB - Lifestyle behaviours have been closely linked to the progressive cell damage associated with oxidative stress (OS) and the development of cardiovascular disease (CVD). Early detection of lifestyle-linked OS may therefore be useful in the early identification of prodromal disease. To test this hypothesis, this study assessed the relationship between a comprehensive redox balance lifestyle score (RBLS) and carotid intima-media thickness (CIMT), a recognized marker for CVD, and plasma biomarkers of OS. In a cross-sectional study design, 100 apparently healthy middle-aged participants were asked to complete a comprehensive lifestyle questionnaire, followed by DXA scanning, CIMT ultrasonography, and blood collection. The RBLS was composed of lifestyle components with pro- and antioxidant properties with a higher score indicative of lower oxidative activity. Multiple linear regression and logistic regression analysis were performed for statistical analysis. The RBLS was significantly associated with the risk for increased CIMT that was independent of conventional CVD risk factors (χ2(9) = 35.60, P ≤ 0.001). The adjusted model explained 42.4% of the variance in CIMT. Participants with RBLS below the median were at significantly increased risk of higher CIMT compared to participants with RBLS above the median (OR = 3.60, 95% CI: 1.19-10.88, P = 0.023). Significant associations were also observed between the RBLS, plasma total antioxidant capacity (TAC) (r(99) = 0.28, P = 0.006), hydroperoxide (HPX) (rs(99) = -0.28, P = 0.005), TAC/HPX ratio (r(98) = 0.41, P ≤ 0.001), γ-glutamyltransferase (r(97) = -0.23, P = 0.024), uric acid (r(98) = -0.20, P = 0.045), and inflammatory C-reactive protein (rs(97) = -0.25, P = 0.012) and interleukin-1β (r(97) = -0.21, P = 0.040). These findings highlight the importance of identifying the collective influence of lifestyle behaviours on OS activity and its potential to remodel the vascular endothelium.

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