A practical and enantiospecific conversion of d-galactose to a substituted α,β-unsaturated δ-lactone synthon

Benjamin E. Stephens, Fei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)


A multi-gram synthesis of a substituted α,β-unsaturated δ-lactone synthon, 1, was developed from commercially available d-galactose. The use of a Horner-Wadsworth-Emmons reaction was able to furnish, with Z selectivity, the enone ester that spontaneously lactonised to provide enantiomerically pure 1.

Original languageEnglish
Pages (from-to)9116-9119
Number of pages4
JournalTetrahedron Letters
Issue number52
Publication statusPublished - 24 Dec 2007


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