A practical approach to differentiate the frontotemporal tauopathy subtypes

Shelley L. Forrest, Glenda M. Halliday, Anastasia Sizemova, Marloes van Roijen, Ciara V. McGinley, Fiona Bright, Milan Kapur, Andrew B. McGeachie, Heather McCann, Claire E. Shepherd, Rachel H. Tan, Andrew J. Affleck, Yue Huang, Jillian J. Kril

Research output: Contribution to journalArticlepeer-review

Abstract

This study proposes a practical approach, using the minimum number of brain regions and stains, to consolidate previously published neuropathological criteria into one operationalized schema to differentiate subtypes of frontotemporal lobar degeneration with tau-immunopositive inclusions (FTLD-tau). This approach uses the superior frontal and precentral cortices and hippocampus stained for phosphorylated-tau, p62 and modified Bielschowsky silver, and the midbrain stained only for modified Bielschowsky silver. Accuracy of interrater reliability was determined by 10 raters in 24 FTLD-tau cases (Pick disease = 4, corticobasal degeneration = 9, progressive supranuclear palsy = 5, globular glial tauopathy = 6) including 4 with a mutation in MAPT collected with consent by Sydney Brain Bank. All brain regions and stains assessed proved informative for accurate pathological subtyping, and many neuropathological features were identified as common across the FTLD-tau subtypes. By identifying subtype-specific neuropathological features in the sections selected, 10 independent observers assigned the cases to a FTLD-tau subtype with almost perfect agreement between raters, emphasizing the requirement for the assessment of subtype-specific features for the accurate subtyping of FTLD-tau. This study consolidates current consensus diagnostic criteria for classifying FTLD-tau subtypes with an efficient, simple and accurate approach that can be implemented in future clinicopathological studies.

Original languageEnglish
Pages (from-to)1122-1126
Number of pages5
JournalJournal of Neuropathology and Experimental Neurology
Volume79
Issue number10
Early online date15 Sep 2020
DOIs
Publication statusPublished - Oct 2020
Externally publishedYes

Keywords

  • Frontotemporal lobar degeneration
  • Pathological classification
  • Tau

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