A quantitative relationship between permeability and the degree of peroxidation in ufasome membranes

Mark Hicks*, Janusz M. Gebicki

*Corresponding author for this work

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Lipoxygenase was used to induce release of sequestered glucose from vesicles made from linoleic acid. Small amounts of peroxide (up to 4-5%) did not produce any significant efflux of glucose, but peroxidation above this level led to a rapid increase in the leakage rate. The maximum rate of glucose efflux was proportional to the rate of peroxidation of the fatty acids in the vesicle membranes.

Original languageEnglish
Pages (from-to)704-708
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume80
Issue number4
DOIs
Publication statusPublished - 28 Feb 1978

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