A quantitative relationship between permeability and the degree of peroxidation in ufasome membranes

Mark Hicks*, Janusz M. Gebicki

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    61 Citations (Scopus)

    Abstract

    Lipoxygenase was used to induce release of sequestered glucose from vesicles made from linoleic acid. Small amounts of peroxide (up to 4-5%) did not produce any significant efflux of glucose, but peroxidation above this level led to a rapid increase in the leakage rate. The maximum rate of glucose efflux was proportional to the rate of peroxidation of the fatty acids in the vesicle membranes.

    Original languageEnglish
    Pages (from-to)704-708
    Number of pages5
    JournalBiochemical and Biophysical Research Communications
    Volume80
    Issue number4
    DOIs
    Publication statusPublished - 28 Feb 1978

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