A randomized controlled trial of cognitive remediation in schizophrenia

Marie Antoinette Redoblado Hodge, Daniella Siciliano, Pamela Withey, Beverley Moss, Genevieve Moore, Gaby Judd, E. Arthur Shores, Anthony Harris

    Research output: Contribution to journalArticlepeer-review

    60 Citations (Scopus)

    Abstract

    Individuals with schizophrenia have consistently been found to exhibit cognitive deficits, which have been identified as critical mediators of psychosocial functional outcomes. Recent reviews of cognitive remediation (CRT) have concluded that these deficits respond to training. This multi-site community study examined 40 individuals with schizophrenia who underwent cognitive remediation using the Neuropsychological Educational Approach to Remediation1 (NEAR). Assessments using the same neuropsychological tests and measures of psychosocial outcome were made at four time points: baseline, before start of active intervention, end of active intervention and 4 months after end of active intervention. Dose of antipsychotic medication remained constant throughout the study period. After participating in NEAR, individuals showed significant improvements in verbal and visual memory, sustained attention and executive functioning. This effect persisted 4 months after the treatment ceased. The average effect size was mild to moderate. Social and occupational outcomes also improved from baseline to post-treatment, which persisted 4 months later. Our findings replicate those of previous studies that suggest that NEAR is effective in improving cognition in individuals with schizophrenia in a naturalistic and ecologically valid setting. Further it extends such findings to show a generalisation of effects to social/occupational outcomes and persistence of effects in the short term.

    Original languageEnglish
    Pages (from-to)419-427
    Number of pages9
    JournalSchizophrenia Bulletin
    Volume36
    Issue number2
    DOIs
    Publication statusPublished - Mar 2010

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