A rapid microfluidic stamping device for studying cardiac stem cells and endothelial cells co-culture

A. H. Barforoushi, J. Shemesh, N. Farbehi, M. Asadnia, G. H. Yeoh, R. E. Nordon, M. E. Warkiani*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

Abstract

Many biological processes in the body are regulated by synchronized activity between two cell types. Recent advances in cell μcontact printing have facilitated the in-vitro study of homotypic and heterotypic cell-cell interaction. However, these techniques are still complicated to perform and are seldom used by biologists. We report here development of a novel microfluidic stamping device for patterning two adherent cell lines with well-defined interlacing configurations to study cell-cell spatial interactions. To demonstrate the stamp's capabilities, we developed an in-vitro model of endothelial and cardiac mesenchymal stem cell interactions, which are thought to regulate coronary repair after myocardial injury.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages1069-1070
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 9 Oct 201613 Oct 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period9/10/1613/10/16

Keywords

  • Co-culture
  • Collective cell migration
  • Microfluidics
  • Stem cells

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