TY - JOUR
T1 - A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles
AU - Sutherland, Mark W.
AU - Gebicki, Janusz M.
PY - 1982
Y1 - 1982
N2 - The oxidation of unsaturated fatty acid micelles by the superoxide free radical (O{minus sign, dot below}
2), during γ irradiation in the presence of formate, is kinetically distinct from oxidation by hydroxyl free radicals (HO.). The evidence suggests that a direct reaction between (O{minus sign, dot below}
2) and lipid hydroperoxide initiates a chain oxidation process in the micelles. While tetranitromethane, which reacts rapidly with (O{minus sign, dot below}
2), protects the micelles from oxidation, active superoxide dismutase is no more effective than its apoprotein, due to lack of penetration of the micellar environment. We discuss these findings in the light of recent literature, and with reference to their possible significance for biological systems.
AB - The oxidation of unsaturated fatty acid micelles by the superoxide free radical (O{minus sign, dot below}
2), during γ irradiation in the presence of formate, is kinetically distinct from oxidation by hydroxyl free radicals (HO.). The evidence suggests that a direct reaction between (O{minus sign, dot below}
2) and lipid hydroperoxide initiates a chain oxidation process in the micelles. While tetranitromethane, which reacts rapidly with (O{minus sign, dot below}
2), protects the micelles from oxidation, active superoxide dismutase is no more effective than its apoprotein, due to lack of penetration of the micellar environment. We discuss these findings in the light of recent literature, and with reference to their possible significance for biological systems.
UR - http://www.scopus.com/inward/record.url?scp=0020057162&partnerID=8YFLogxK
U2 - 10.1016/0003-9861(82)90001-7
DO - 10.1016/0003-9861(82)90001-7
M3 - Article
C2 - 6282219
AN - SCOPUS:0020057162
VL - 214
SP - 1
EP - 11
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
SN - 0003-9861
IS - 1
ER -