A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions

Masateru Furusato*, Tomohiro Shima, Yuma Kokuzawa, Kazuhiko Ito, Takashi Tanaka, Kiyotaka Iwasaki, Yi Qian, Mitsuo Umezu, Zhi Kun Yan, Ling Zhu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

2 Citations (Scopus)

Abstract

A novel in vitro mock circulatory system, which enables to reproduce an inflow restriction, simulating blood volume pooling due to heart failure, was developed to evaluate a hydrodynamic performance of a pulsatile ventricular assist device (VAD) in practical conditions. The concept of this development was motivated by a difference of an inflow restriction between in vitro and in vivo environments. The major idea of this study is to reproduce an inflow restriction by using a centrifugal pump placed at an inflow side of a left ventricular model instead of a constant head reservoir in a conventional circuit. In the novel circuit, the maximum flow rate was obtained at lower systolic fraction as compared with a conventional circuit. This similar tendency by the novel one was observed in an acute animal experiment in sheep. This result suggests that a new mock circuit is effective to confirm a practical drive strategy of the VAD for various diseased conditions.

Original languageEnglish
Title of host publicationLife System Modeling and Simulation - International Conference, LSMS 2007, Proceedings
EditorsKang Li, Xin Li, George William Irwin, Gusen He
Place of PublicationBerlin ; New York
PublisherSpringer, Springer Nature
Pages553-558
Number of pages6
Volume4689 LNBI
ISBN (Print)9783540747703
Publication statusPublished - 2007
Externally publishedYes
Event2007 International Conference on Life System Modeling and Simulation, LSMS 2007 - Shanghai, China
Duration: 14 Sep 200717 Sep 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4689 LNBI
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other2007 International Conference on Life System Modeling and Simulation, LSMS 2007
CountryChina
CityShanghai
Period14/09/0717/09/07

Fingerprint Dive into the research topics of 'A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions'. Together they form a unique fingerprint.

Cite this