A review of methods for detecting melamine in food samples

Yang Lu, Yinqiang Xia, Guozhen Liu, Mingfei Pan, Mengjuan Li, Nanju Alice Lee, Shuo Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)


Melamine is a synthetic chemical used in the manufacture of resins, pigments, and superplasticizers. Human beings can be exposed to melamine through various sources such as migration from related products into foods, pesticide contamination, and illegal addition to foods. Toxicity studies suggest that prolonged consumption of melamine could lead to the formation of kidney stones or even death. Therefore, reliable and accurate detection methods are essential to prevent human exposure to melamine. Sample preparation is of critical importance, since it could directly affect the performance of analytical methods. Some methods for the detection of melamine include instrumental analysis, immunoassays, and sensor methods. In this paper, we have summarized the state-of-the-art methods used for food sample preparation as well as the various detection techniques available for melamine. Combinations of multiple techniques and new materials used in the detection of melamine have also been reviewed. Finally, future perspectives on the applications of microfluidic devices have also been provided.

Original languageEnglish
Pages (from-to)51-66
Number of pages16
JournalCritical Reviews in Analytical Chemistry
Issue number1
Publication statusPublished - 2017


  • Biosensors
  • chemosensors
  • immunoassay
  • instrumental analysis
  • melamine


Dive into the research topics of 'A review of methods for detecting melamine in food samples'. Together they form a unique fingerprint.

Cite this