A RhoA-derived peptide inhibits human immunodeficiency Virus-1 entry In Vitro

Maciej Maselko; Casey Ward; Manoj Pastey

doi:10.2174/157016211794582605

A RhoA-derived peptide inhibits human immunodeficiency Virus-1 entry In Vitro

Maciej Maselko, Casey Ward, Manoj Pastey^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA_77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Current HIV Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.2174/157016211794582605
Publication status	Published - 22 Feb 2011
Externally published	Yes

Keywords

antiviral
HIV-1
peptides
RhoA

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AB - RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

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A RhoA-derived peptide inhibits human immunodeficiency Virus-1 entry In Vitro

Abstract

Keywords

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