TY - JOUR
T1 - A Ruthenium Based Organometallic Complex for Biosensing that is both a Stable Redox Label and a Homobifunctional Linker
AU - Lee, Yeng Ying
AU - Parker, Stephen G.
AU - Barfidokht, Abbas
AU - Alam, Muhammad Tanzirul
AU - Walker, D. Barney
AU - Messerle, Barbara A.
AU - Gooding, J. Justin
PY - 2015/5/1
Y1 - 2015/5/1
N2 - A stable ruthenium-based redox label, Ru(acetylacetonate)2(bipyridine-NH2), has been synthesized with the target of circumventing the problem associated with the use of ferrocene for biosensing in solutions containing chloride ions. The redox species was shown to be highly stable with repeated cycling in biological buffers as well as being amenable to surface coupling reactions. To demonstrate the latter, the redox label was anchored onto a self-assembled monolayer of 6-mercaptohexanoic acid, using carbodiimide coupling, followed by binding of a pentapeptide to the redox label.
AB - A stable ruthenium-based redox label, Ru(acetylacetonate)2(bipyridine-NH2), has been synthesized with the target of circumventing the problem associated with the use of ferrocene for biosensing in solutions containing chloride ions. The redox species was shown to be highly stable with repeated cycling in biological buffers as well as being amenable to surface coupling reactions. To demonstrate the latter, the redox label was anchored onto a self-assembled monolayer of 6-mercaptohexanoic acid, using carbodiimide coupling, followed by binding of a pentapeptide to the redox label.
UR - http://www.scopus.com/inward/record.url?scp=84929134391&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/arc/LP100200593
U2 - 10.1002/elan.201400642
DO - 10.1002/elan.201400642
M3 - Article
AN - SCOPUS:84929134391
SN - 1040-0397
VL - 27
SP - 1078
EP - 1085
JO - Electroanalysis
JF - Electroanalysis
IS - 5
ER -