A safe-by-design approach for the synthesis of a novel cross-linked hyaluronic acid with improved biological and physical properties

Sabrina Sciabica; Riccardo Barbari; Riccardo Fontana; Giovanni Tafuro; Alessandra Semenzato; Daniela Traini; Dina M. Silva; Larissa Gomes Dos Reis; Luisa Canilli; Massimo Terno; Peggy Marconi; Anna Baldisserotto; Silvia Vertuani; Stefano Manfredini

doi:10.3390/ph16030431

A safe-by-design approach for the synthesis of a novel cross-linked hyaluronic acid with improved biological and physical properties

Sabrina Sciabica, Riccardo Barbari, Riccardo Fontana, Giovanni Tafuro, Alessandra Semenzato, Daniela Traini, Dina M. Silva, Larissa Gomes Dos Reis, Luisa Canilli, Massimo Terno, Peggy Marconi, Anna Baldisserotto, Silvia Vertuani, Stefano Manfredini

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

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Abstract

Hyaluronic acid (HA) is a polymer with unique biological properties that has gained in interest over the years, with applications in pharmaceutical, cosmetic, and biomedical fields; however, its widespread use has been limited by its short half-life. Therefore, a new cross-linked hyaluronic acid was designed and characterized using a natural and safe cross-linking agent, such as arginine methyl ester, which provided improved resistance to enzymatic action, as compared to the corresponding linear polymer. The antibacterial profile of the new derivative was shown to be effective against S. aureus and P. acnes, making it a promising candidate for use in cosmetic formulations and skin applications. Its effect on S. pneumoniae, combined with its excellent tolerability profile on lung cells, also makes this new product suitable for applications involving the respiratory tract.

Original language	English
Article number	431
Pages (from-to)	1-20
Number of pages	20
Journal	Pharmaceuticals
Volume	16
Issue number	3
DOIs	https://doi.org/10.3390/ph16030431
Publication status	Published - 11 Mar 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

hyaluronic acid
arginine
cross-linking
bioactivity
cosmeceutical
skin
lung

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10.3390/ph16030431Licence: CC BY

Publisher version (open access)Final published version, 3.7 MBLicence: CC BY

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Sciabica, S., Barbari, R., Fontana, R., Tafuro, G., Semenzato, A., Traini, D., Silva, D. M., Gomes Dos Reis, L., Canilli, L., Terno, M., Marconi, P., Baldisserotto, A., Vertuani, S., & Manfredini, S. (2023). A safe-by-design approach for the synthesis of a novel cross-linked hyaluronic acid with improved biological and physical properties. Pharmaceuticals, 16(3), 1-20. Article 431. https://doi.org/10.3390/ph16030431

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abstract = "Hyaluronic acid (HA) is a polymer with unique biological properties that has gained in interest over the years, with applications in pharmaceutical, cosmetic, and biomedical fields; however, its widespread use has been limited by its short half-life. Therefore, a new cross-linked hyaluronic acid was designed and characterized using a natural and safe cross-linking agent, such as arginine methyl ester, which provided improved resistance to enzymatic action, as compared to the corresponding linear polymer. The antibacterial profile of the new derivative was shown to be effective against S. aureus and P. acnes, making it a promising candidate for use in cosmetic formulations and skin applications. Its effect on S. pneumoniae, combined with its excellent tolerability profile on lung cells, also makes this new product suitable for applications involving the respiratory tract.",

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Sciabica, S, Barbari, R, Fontana, R, Tafuro, G, Semenzato, A, Traini, D, Silva, DM, Gomes Dos Reis, L, Canilli, L, Terno, M, Marconi, P, Baldisserotto, A, Vertuani, S & Manfredini, S 2023, 'A safe-by-design approach for the synthesis of a novel cross-linked hyaluronic acid with improved biological and physical properties', Pharmaceuticals, vol. 16, no. 3, 431, pp. 1-20. https://doi.org/10.3390/ph16030431

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AU - Terno, Massimo

AU - Marconi, Peggy

AU - Baldisserotto, Anna

AU - Vertuani, Silvia

AU - Manfredini, Stefano

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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A safe-by-design approach for the synthesis of a novel cross-linked hyaluronic acid with improved biological and physical properties

Abstract

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Keywords

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