A second Australian family with hemoglobin north shore (β134 val→glu)

Howard Gurney; Ibrahim Baig; Susan Gordon; Kiran Phadke; Heather Kearsley; Pat Fleming; Ken Wyatt; Wilbur Hughes

A second Australian family with hemoglobin north shore (β134 val→glu)

Howard Gurney, Ibrahim Baig, Susan Gordon^*, Kiran Phadke, Heather Kearsley, Pat Fleming, Ken Wyatt, Wilbur Hughes

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A second Australian family is reported with Hemoglobin North Shore (β134 Val→Glu), an unstable hemoglobin, causing no clinical symptoms. All affected family members showed only mild reticulocytosis and microcytosis on the blood film, despite the strongly positive isopropanol test for Hb (hemoglobin) stability and numerous red cell inclusions. Hb North Shore constituted 31-38% of the total hemoglobin and migrated on the anodal side of Hb A at pH 8.9. The association of a mildly raised Hb A2 level and thalassemic phenotype with Hb North Shore previously reported, is confirmed in this study.

Original language	English
Pages (from-to)	62-63
Number of pages	2
Journal	Pathology
Volume	19
Issue number	1
Publication status	Published - 1987
Externally published	Yes

Keywords

Raised Hb A2
Red cell inclusions
Unstable hemoglobin

Cite this

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title = "A second Australian family with hemoglobin north shore (β134 val→glu)",

abstract = "A second Australian family is reported with Hemoglobin North Shore (β134 Val→Glu), an unstable hemoglobin, causing no clinical symptoms. All affected family members showed only mild reticulocytosis and microcytosis on the blood film, despite the strongly positive isopropanol test for Hb (hemoglobin) stability and numerous red cell inclusions. Hb North Shore constituted 31-38% of the total hemoglobin and migrated on the anodal side of Hb A at pH 8.9. The association of a mildly raised Hb A2 level and thalassemic phenotype with Hb North Shore previously reported, is confirmed in this study.",

keywords = "Raised Hb A2, Red cell inclusions, Unstable hemoglobin",

author = "Howard Gurney and Ibrahim Baig and Susan Gordon and Kiran Phadke and Heather Kearsley and Pat Fleming and Ken Wyatt and Wilbur Hughes",

year = "1987",

language = "English",

volume = "19",

pages = "62--63",

journal = "Pathology",

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T1 - A second Australian family with hemoglobin north shore (β134 val→glu)

AU - Gurney, Howard

AU - Baig, Ibrahim

AU - Gordon, Susan

AU - Phadke, Kiran

AU - Kearsley, Heather

AU - Fleming, Pat

AU - Wyatt, Ken

AU - Hughes, Wilbur

PY - 1987

Y1 - 1987

N2 - A second Australian family is reported with Hemoglobin North Shore (β134 Val→Glu), an unstable hemoglobin, causing no clinical symptoms. All affected family members showed only mild reticulocytosis and microcytosis on the blood film, despite the strongly positive isopropanol test for Hb (hemoglobin) stability and numerous red cell inclusions. Hb North Shore constituted 31-38% of the total hemoglobin and migrated on the anodal side of Hb A at pH 8.9. The association of a mildly raised Hb A2 level and thalassemic phenotype with Hb North Shore previously reported, is confirmed in this study.

AB - A second Australian family is reported with Hemoglobin North Shore (β134 Val→Glu), an unstable hemoglobin, causing no clinical symptoms. All affected family members showed only mild reticulocytosis and microcytosis on the blood film, despite the strongly positive isopropanol test for Hb (hemoglobin) stability and numerous red cell inclusions. Hb North Shore constituted 31-38% of the total hemoglobin and migrated on the anodal side of Hb A at pH 8.9. The association of a mildly raised Hb A2 level and thalassemic phenotype with Hb North Shore previously reported, is confirmed in this study.

KW - Raised Hb A2

KW - Red cell inclusions

KW - Unstable hemoglobin

UR - http://www.scopus.com/inward/record.url?scp=0023137695&partnerID=8YFLogxK

M3 - Article

C2 - 3588028

AN - SCOPUS:0023137695

SN - 0031-3025

VL - 19

SP - 62

EP - 63

JO - Pathology

JF - Pathology

IS - 1

ER -

A second Australian family with hemoglobin north shore (β134 val→glu)

Abstract

Keywords

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