A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy

Sonja Porsche; Martin Klietz; Stephan Greten; Ines A. Piot; Ida Jensen; Florian Wegner; Lan Ye; Lea Krey; Matthias Höllerhage; Monika Pötter-Nerger; Molly Zeitzschel; Keno Hagena; Jan Kassubek; Patrick Süß; Jürgen Winkler; Daniela Berg; Steffen Paschen; Lars Tönges; Doreen Gruber; Florin Gandor; Wolfgang H. Jost; Andrea A. Kühn; Inga Claus; Tobias Warnecke; David J. Pedrosa; Carsten Eggers; Claudia Trenkwalder; Joseph Classen; Johannes Schwarz; Alfons Schnitzler; Patricia Krause; Anja Schneider; Moritz Brandt; Björn Falkenburger; Inga Zerr; Mathias Bähr; Endy Weidinger; Johannes Levin; Sabrina Katzdobler; Emrah Düzel; Wenzel Glanz; Stefan Teipel; Ingo Kilimann; Johannes Prudlo; Thomas Gasser; Kathrin Brockmann; Annika Spottke; Anna Esser; Gabor C. Petzold; Gesine Respondek; Günter U. Höglinger

doi:10.1002/mdc3.14348

A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy

Sonja Porsche, Martin Klietz^*, Stephan Greten, Ines A. Piot, Ida Jensen, Florian Wegner, Lan Ye, Lea Krey, Matthias Höllerhage, Monika Pötter-Nerger, Molly Zeitzschel, Keno Hagena, Jan Kassubek, Patrick Süß, Jürgen Winkler, Daniela Berg, Steffen Paschen, Lars Tönges, Doreen Gruber, Florin GandorWolfgang H. Jost, Andrea A. Kühn, Inga Claus, Tobias Warnecke, David J. Pedrosa, Carsten Eggers, Claudia Trenkwalder, Joseph Classen, Johannes Schwarz, Alfons Schnitzler, Patricia Krause, Anja Schneider, Moritz Brandt, Björn Falkenburger, Inga Zerr, Mathias Bähr, Endy Weidinger, Johannes Levin, Sabrina Katzdobler, Emrah Düzel, Wenzel Glanz, Stefan Teipel, Ingo Kilimann, Johannes Prudlo, Thomas Gasser, Kathrin Brockmann, Annika Spottke, Anna Esser, Gabor C. Petzold, Gesine Respondek, Günter U. Höglinger

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing. Objectives: To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP. Methods: The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed. Results: Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = −0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022). Conclusions: The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.

Original language	English
Pages (from-to)	764-774
Number of pages	11
Journal	Movement Disorders Clinical Practice
Volume	12
Issue number	6
Early online date	27 Jan 2025
DOIs	https://doi.org/10.1002/mdc3.14348
Publication status	Published - Jun 2025
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

4-repeat tauopathies
cognition
depression
Progressive Supranuclear Palsy
quality of life

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10.1002/mdc3.14348Licence: CC BY

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Porsche, S., Klietz, M., Greten, S., Piot, I. A., Jensen, I., Wegner, F., Ye, L., Krey, L., Höllerhage, M., Pötter-Nerger, M., Zeitzschel, M., Hagena, K., Kassubek, J., Süß, P., Winkler, J., Berg, D., Paschen, S., Tönges, L., Gruber, D., ... Höglinger, G. U. (2025). A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy. Movement Disorders Clinical Practice, 12(6), 764-774. https://doi.org/10.1002/mdc3.14348

@article{1be04096cc914beeab516859c1b06d1c,

title = "A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy",

abstract = "Background: Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing. Objectives: To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP. Methods: The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed. Results: Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = −0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022). Conclusions: The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.",

keywords = "4-repeat tauopathies, cognition, depression, Progressive Supranuclear Palsy, quality of life",

author = "Sonja Porsche and Martin Klietz and Stephan Greten and Piot, \{Ines A.\} and Ida Jensen and Florian Wegner and Lan Ye and Lea Krey and Matthias H{\"o}llerhage and Monika P{\"o}tter-Nerger and Molly Zeitzschel and Keno Hagena and Jan Kassubek and Patrick S{\"u}{\ss} and J{\"u}rgen Winkler and Daniela Berg and Steffen Paschen and Lars T{\"o}nges and Doreen Gruber and Florin Gandor and Jost, \{Wolfgang H.\} and K{\"u}hn, \{Andrea A.\} and Inga Claus and Tobias Warnecke and Pedrosa, \{David J.\} and Carsten Eggers and Claudia Trenkwalder and Joseph Classen and Johannes Schwarz and Alfons Schnitzler and Patricia Krause and Anja Schneider and Moritz Brandt and Bj{\"o}rn Falkenburger and Inga Zerr and Mathias B{\"a}hr and Endy Weidinger and Johannes Levin and Sabrina Katzdobler and Emrah D{\"u}zel and Wenzel Glanz and Stefan Teipel and Ingo Kilimann and Johannes Prudlo and Thomas Gasser and Kathrin Brockmann and Annika Spottke and Anna Esser and Petzold, \{Gabor C.\} and Gesine Respondek and H{\"o}glinger, \{G{\"u}nter U.\}",

note = "Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2025",

month = jun,

doi = "10.1002/mdc3.14348",

language = "English",

volume = "12",

pages = "764--774",

journal = "Movement Disorders Clinical Practice",

issn = "2330-1619",

publisher = "John Wiley \& Sons",

number = "6",

}

Porsche, S, Klietz, M, Greten, S, Piot, IA, Jensen, I, Wegner, F, Ye, L, Krey, L, Höllerhage, M, Pötter-Nerger, M, Zeitzschel, M, Hagena, K, Kassubek, J, Süß, P, Winkler, J, Berg, D, Paschen, S, Tönges, L, Gruber, D, Gandor, F, Jost, WH, Kühn, AA, Claus, I, Warnecke, T, Pedrosa, DJ, Eggers, C, Trenkwalder, C, Classen, J, Schwarz, J, Schnitzler, A, Krause, P, Schneider, A, Brandt, M, Falkenburger, B, Zerr, I, Bähr, M, Weidinger, E, Levin, J, Katzdobler, S, Düzel, E, Glanz, W, Teipel, S, Kilimann, I, Prudlo, J, Gasser, T, Brockmann, K, Spottke, A, Esser, A, Petzold, GC, Respondek, G & Höglinger, GU 2025, 'A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy', Movement Disorders Clinical Practice, vol. 12, no. 6, pp. 764-774. https://doi.org/10.1002/mdc3.14348

TY - JOUR

T1 - A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy

AU - Porsche, Sonja

AU - Klietz, Martin

AU - Greten, Stephan

AU - Piot, Ines A.

AU - Jensen, Ida

AU - Wegner, Florian

AU - Ye, Lan

AU - Krey, Lea

AU - Höllerhage, Matthias

AU - Pötter-Nerger, Monika

AU - Zeitzschel, Molly

AU - Hagena, Keno

AU - Kassubek, Jan

AU - Süß, Patrick

AU - Winkler, Jürgen

AU - Berg, Daniela

AU - Paschen, Steffen

AU - Tönges, Lars

AU - Gruber, Doreen

AU - Gandor, Florin

AU - Jost, Wolfgang H.

AU - Kühn, Andrea A.

AU - Claus, Inga

AU - Warnecke, Tobias

AU - Pedrosa, David J.

AU - Eggers, Carsten

AU - Trenkwalder, Claudia

AU - Classen, Joseph

AU - Schwarz, Johannes

AU - Schnitzler, Alfons

AU - Krause, Patricia

AU - Schneider, Anja

AU - Brandt, Moritz

AU - Falkenburger, Björn

AU - Zerr, Inga

AU - Bähr, Mathias

AU - Weidinger, Endy

AU - Levin, Johannes

AU - Katzdobler, Sabrina

AU - Düzel, Emrah

AU - Glanz, Wenzel

AU - Teipel, Stefan

AU - Kilimann, Ingo

AU - Prudlo, Johannes

AU - Gasser, Thomas

AU - Brockmann, Kathrin

AU - Spottke, Annika

AU - Esser, Anna

AU - Petzold, Gabor C.

AU - Respondek, Gesine

AU - Höglinger, Günter U.

N1 - Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2025/6

Y1 - 2025/6

N2 - Background: Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing. Objectives: To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP. Methods: The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed. Results: Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = −0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022). Conclusions: The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.

AB - Background: Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and neuropsychiatric disability in PSP is still missing. Objectives: To create and validate a new scale for cognitive and neuropsychiatric impairment in PSP. Methods: The Short Cognitive and Neuropsychiatric (ShoCo) scale was developed containing five items (bradyphrenia, apathy, aphasia, dysexecution and disinhibition). Each item can be categorized into 0 = no deficit, 1 = mild deficit, 2 = moderate deficit and 3 = severe deficit. The total score includes 15 points, 0 meaning no deficit and 15 severe deficits. Cross-sectional and longitudinal data from 201 baseline and 71 follow up patients were analyzed. Results: Baseline ShoCo scale results were 5.9 ± 2.9. No significant differences between patients with Richardson syndrome (PSP-RS) and variants (vPSP) could be detected in the PSP-ShoCo scale scores (PSP-RS 6.1 ± 3.0, n = 160, vPSP 5.1 ± 2.6, n = 41, P = 0.057). The scale showed good correlation with established scores (eg, Montreal cognitive assessment r = −0.535, P = 0.001). The ShoCo scale showed significant annualized change within the PSP-RS patients (baseline 6.2 ± 2.9, follow up 6.9 ± 3.1, annualized diff. 1.0 ± 3.1, n = 57, P = 0.022). Conclusions: The ShoCo scale seems a promising and valid tool to measure specific neuropsychological disabilities of PSP patients in clinical routine and research.

KW - 4-repeat tauopathies

KW - cognition

KW - depression

KW - Progressive Supranuclear Palsy

KW - quality of life

UR - https://www.scopus.com/pages/publications/85216262062

U2 - 10.1002/mdc3.14348

DO - 10.1002/mdc3.14348

M3 - Article

C2 - 39868903

SN - 2330-1619

VL - 12

SP - 764

EP - 774

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 6

ER -

A short cognitive and neuropsychiatric assessment scale for progressive supranuclear palsy

Abstract

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Keywords

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