A simplified method for quantifying the subject-specific relationship between blood pressure and carotid-femoral pulse wave velocity

Mark Butlin, Peta J. Hathway, Zahra Kouchaki, Karen Peebles, Alberto P. Avolio

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

6 Citations (Scopus)

Abstract

Devices that estimate blood pressure from arterial pulse wave velocity (PWV) potentially provide continuous, ambulatory blood pressure monitoring. Accurate blood pressure estimation requires reliable quantification of the relationship between blood pressure and PWV. Regression to population normal values or, when using limb artery PWV, changing hydrostatic blood pressure within the limb provides a calibration index. Population lookup tables require accurate anthropometric correlates, assuming no individual variation. Only devices that measure PWV in the limb can use limb position changes. This study proposes a method for developing a calibration curve independent of lookup tables and useful for large artery PWV measurement, such as carotid-femoral PWV (PWVcf). PWVcf was measured in 27 normal subjects (15 female, 36±19 years) in both the supine and standing position. The change in systemic pressure was measured and hydrostatic pressure change calculated from estimated vessel path length height, measured using body surface distances. Brachial diastolic blood pressure increased for all subjects from supine to standing (supine 70±8 mmHg, standing 83±8 mmHg, p<0.001) with an additional hydrostatic change across the carotid-femoral path length of 19±2 mmHg (p<0.001). PWVcf also increased in all subjects (supine 5.2±1.3 m/s, standing 7.3±2.2 m/s, p<0.001). The subject-specific calibration index (ΔDP/ΔPWVcf) varied amongst the cohort (20±8 mmHg/m/s), was correlated with age (-0.57, p=0.002) and seated aortic systolic pressure (-0.38, p=0.048) and was always greater than zero. Thus, this study describes a simple but novel method of measuring an individualized calibration index using blood pressure and PWV measurements in the supine and standing position.

Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Place of PublicationNew York
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages5708-5711
Number of pages4
ISBN (Electronic)9781424492718
DOIs
Publication statusPublished - 4 Nov 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: 25 Aug 201529 Aug 2015

Publication series

NameIEEE Engineering in Medicine and Biology Society Conference Proceedings
PublisherIEEE
ISSN (Print)1557-170X

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period25/08/1529/08/15

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Butlin, M., Hathway, P. J., Kouchaki, Z., Peebles, K., & Avolio, A. P. (2015). A simplified method for quantifying the subject-specific relationship between blood pressure and carotid-femoral pulse wave velocity. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 (pp. 5708-5711). [7319688] (IEEE Engineering in Medicine and Biology Society Conference Proceedings). New York: Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/EMBC.2015.7319688