A stochastic model of the electrically stimulated auditory nerve: Single-pulse response

Lan C. Bruce, Mark W. White, Laurence S. Irlicht, Stephen J. O'Leary, Scott Dynes, Eric Javel, Graeme M. Clark

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)

Abstract

Most models of neural response to electrical stimulation, such as the Hodgkin-Huxley equations, are deterministic, despite significant physiological evidence for the existence of stochastic activity. For instance, the range of discharge probabilities measured in response to single electrical pulses cannot be explained at all by deterministic models. Furthermore, there is growing evidence that the stochastic component of auditory nerve response to electrical stimulation may be fundamental to functionally significant physiological and psychophysical phenomena. In this paper we present a simple and computationally efficient stochastic model of single-fiber response to single biphasic electrical pulses, based on a deterministic threshold model of action potential generation. Comparisons with physiological data from cat auditory nerve fibers are made, and it is shown that the stochastic model predicts discharge probabilities measured in response to single biphasic pulses more accurately than does the equivalent deterministic model. In addition, physiological data show an increase in stochastic activity with increasing pulse width of anodic/cathodic biphasic pulses, a phenomenon not present for monophasic stimuli. These and other data from the auditory nerve are then used to develop a population model of the total auditory nerve, where each fiber is described by the single-fiber model.

Original languageEnglish
Pages (from-to)617-629
Number of pages13
JournalIEEE Transactions on Biomedical Engineering
Volume46
Issue number6
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Auditory nerve
  • Cochlear implant
  • Functional electrical stimulation
  • Population response
  • Sensory prosthesis
  • Single-pulse response
  • Stochastic threshold model

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