A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Emiliano Tamanini, Arna Katewa, Lisa M. Sedger, Matthew H. Todd, Michael Watkinson*

*Corresponding author for this work

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalInorganic Chemistry
Volume48
Issue number1
DOIs
Publication statusPublished - 5 Jan 2009

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    Tamanini, E., Katewa, A., Sedger, L. M., Todd, M. H., & Watkinson, M. (2009). A synthetically simple, click-generated cyclam-based zinc(ll) sensor. Inorganic Chemistry, 48(1), 319-324. https://doi.org/10.1021/ic8017634