Abstract
A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death.
Original language | English |
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Pages (from-to) | 319-324 |
Number of pages | 6 |
Journal | Inorganic Chemistry |
Volume | 48 |
Issue number | 1 |
DOIs | |
Publication status | Published - 5 Jan 2009 |