Abstract
A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death.
| Original language | English |
|---|---|
| Pages (from-to) | 319-324 |
| Number of pages | 6 |
| Journal | Inorganic Chemistry |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 5 Jan 2009 |
Fingerprint Dive into the research topics of 'A synthetically simple, click-generated cyclam-based zinc(ll) sensor'. Together they form a unique fingerprint.
Cite this
Tamanini, E., Katewa, A., Sedger, L. M., Todd, M. H., & Watkinson, M. (2009). A synthetically simple, click-generated cyclam-based zinc(ll) sensor. Inorganic Chemistry, 48(1), 319-324. https://doi.org/10.1021/ic8017634