A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Emiliano Tamanini; Arna Katewa; Lisa M. Sedger; Matthew H. Todd; Michael Watkinson

doi:10.1021/ic8017634

A synthetically simple, click-generated cyclam-based zinc(ll) sensor

Emiliano Tamanini, Arna Katewa, Lisa M. Sedger, Matthew H. Todd, Michael Watkinson^*

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

164 Citations (Scopus)

Abstract

A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death.

Original language	English
Pages (from-to)	319-324
Number of pages	6
Journal	Inorganic Chemistry
Volume	48
Issue number	1
DOIs	https://doi.org/10.1021/ic8017634
Publication status	Published - 5 Jan 2009

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AU - Watkinson, Michael

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A synthetically simple, click-generated cyclam-based zinc(ll) sensor

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