A systematic review and meta-analysis of cold in situ perfusion and preservation for pancreas transplantation

Ahmer M. Hameed, Germaine Wong, Jerome M. Laurence, Vincent W. T. Lam, Henry C. Pleass, Wayne J. Hawthorne*

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Citations (Scopus)
15 Downloads (Pure)

Abstract

Background: This study aimed to identify the most effective solution for in situ perfusion/preservation of the pancreas in donation after brain death donors, in addition to optimal in situ flush volume(s) and route(s) during pancreas procurement. Methods: Embase, Medline and Cochrane databases were utilized (1980–2017). Articles comparing graft outcomes between two or more different perfusion/preservation fluids (University of Wisconsin (UW), histidine–tryptophan–ketoglutarate (HTK) and/or Celsior) were compared using random effects models where appropriate. Results: Thirteen articles were included (939 transplants). Confidence in available evidence was low. A higher serum peak lipase (standardized mean difference 0.47, 95% CI 0.23–0.71, I2 = 0) was observed in pancreatic grafts perfused/preserved with HTK compared to UW, but there were no differences in one-month pancreas allograft survivals or early thrombotic graft loss rates. Similarly, there were no significant differences in the rates of graft pancreatitis, thrombosis and graft survival between UW and Celsior solutions, and between aortic-only and dual aorto-portal perfusion. Conclusion: UW cold perfusion may reduce peak serum lipase, but no quality evidence suggested UW cold perfusion improves graft survival and reduces thrombosis rates. Further research is needed to establish longer-term graft outcomes, the comparative efficacy of Celsior, and ideal perfusion volumes.

Original languageEnglish
Pages (from-to)933-943
Number of pages11
JournalHPB
Volume19
Issue number11
DOIs
Publication statusPublished - 1 Nov 2017
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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