TY - JOUR
T1 - A systematic review and meta-analysis of cold in situ perfusion and preservation for pancreas transplantation
AU - Hameed, Ahmer M.
AU - Wong, Germaine
AU - Laurence, Jerome M.
AU - Lam, Vincent W. T.
AU - Pleass, Henry C.
AU - Hawthorne, Wayne J.
N1 - Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background: This study aimed to identify the most effective solution for in situ perfusion/preservation of the pancreas in donation after brain death donors, in addition to optimal in situ flush volume(s) and route(s) during pancreas procurement. Methods: Embase, Medline and Cochrane databases were utilized (1980–2017). Articles comparing graft outcomes between two or more different perfusion/preservation fluids (University of Wisconsin (UW), histidine–tryptophan–ketoglutarate (HTK) and/or Celsior) were compared using random effects models where appropriate. Results: Thirteen articles were included (939 transplants). Confidence in available evidence was low. A higher serum peak lipase (standardized mean difference 0.47, 95% CI 0.23–0.71, I2 = 0) was observed in pancreatic grafts perfused/preserved with HTK compared to UW, but there were no differences in one-month pancreas allograft survivals or early thrombotic graft loss rates. Similarly, there were no significant differences in the rates of graft pancreatitis, thrombosis and graft survival between UW and Celsior solutions, and between aortic-only and dual aorto-portal perfusion. Conclusion: UW cold perfusion may reduce peak serum lipase, but no quality evidence suggested UW cold perfusion improves graft survival and reduces thrombosis rates. Further research is needed to establish longer-term graft outcomes, the comparative efficacy of Celsior, and ideal perfusion volumes.
AB - Background: This study aimed to identify the most effective solution for in situ perfusion/preservation of the pancreas in donation after brain death donors, in addition to optimal in situ flush volume(s) and route(s) during pancreas procurement. Methods: Embase, Medline and Cochrane databases were utilized (1980–2017). Articles comparing graft outcomes between two or more different perfusion/preservation fluids (University of Wisconsin (UW), histidine–tryptophan–ketoglutarate (HTK) and/or Celsior) were compared using random effects models where appropriate. Results: Thirteen articles were included (939 transplants). Confidence in available evidence was low. A higher serum peak lipase (standardized mean difference 0.47, 95% CI 0.23–0.71, I2 = 0) was observed in pancreatic grafts perfused/preserved with HTK compared to UW, but there were no differences in one-month pancreas allograft survivals or early thrombotic graft loss rates. Similarly, there were no significant differences in the rates of graft pancreatitis, thrombosis and graft survival between UW and Celsior solutions, and between aortic-only and dual aorto-portal perfusion. Conclusion: UW cold perfusion may reduce peak serum lipase, but no quality evidence suggested UW cold perfusion improves graft survival and reduces thrombosis rates. Further research is needed to establish longer-term graft outcomes, the comparative efficacy of Celsior, and ideal perfusion volumes.
UR - http://www.scopus.com/inward/record.url?scp=85028299718&partnerID=8YFLogxK
U2 - 10.1016/j.hpb.2017.07.012
DO - 10.1016/j.hpb.2017.07.012
M3 - Review article
C2 - 28844527
AN - SCOPUS:85028299718
SN - 1365-182X
VL - 19
SP - 933
EP - 943
JO - HPB
JF - HPB
IS - 11
ER -