A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions

L. Si, T. M. Winzenberg, B. De Graaff, A. J. Palmer

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

This study aimed to statistically combine multiple health state utility values (HSUVs) reported in the literature for patients with osteoporosis and osteoporotic fractures. Fracture events were associated with decrements in HSUVs which differed between fracture sites. We have provided summary values for use in future health economics analyses in osteoporosis. Osteoporotic fractures have high financial and health burden. Economic evaluations on osteoporotic fracture prevention have been frequently performed in past decades. One of the challenges in the economic evaluations was to identify consistent health state utility values (HSUVs) to use for osteoporotic fracture-related conditions. The objective of this study was to determine summary measures of multiple HSUVs reported in the literature for patients with osteoporosis and osteoporotic fractures. We performed a systematic review, meta-analysis and meta-regression of published literature that reported HSUVs for osteoporotic fracture-related conditions. There were 62 studies representing 142,477 patients included. In total, 362 HSUVs were identified: 106 for pre-fracture; 89 for post-hip fracture; 130 for post-vertebral fracture and 37 for post-wrist fracture. The pooled HSUVs, using a random-effects model were 0.76 (95 % CI 0.75, 0.77, I 2=0.99) for pre-fracture; 0.57 (95 % CI 0.52, 0.63, I 2=1) for post-hip fracture; 0.59 (95 % CI 0.55, 0.62, I 2=0.99) for post-vertebral facture and 0.72 (95 % CI 0.67, 0.78, I 2=1) for post-wrist fracture. Heterogeneities were addressed through meta-regression. HSUVs immediately following hip, vertebral and wrist fractures were 0.31, 0.44 and 0.61, respectively. Patients' HSUVs improved over time following fracture events: HSUVs for the first year after hip, vertebral and wrist fractures were 0.59, 0.55 and 0.78, respectively; and 0.66, 0.66 and 0.81 for subsequent years. Fractures were associated with significant decrements in HSUVs. This study provides a standard set of HSUVs that can be used in health economic assessments in osteoporosis.

LanguageEnglish
Pages1987-1997
Number of pages11
JournalOsteoporosis International
Volume25
Issue number8
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Osteoporosis
Meta-Analysis
Quality of Life
Health
Osteoporotic Fractures
Wrist
Hip Fractures
Cost-Benefit Analysis
Hip
Economics

Keywords

  • Health state utility value
  • Osteoporosis
  • Quality of life
  • Utilities

Cite this

Si, L. ; Winzenberg, T. M. ; De Graaff, B. ; Palmer, A. J. / A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions. In: Osteoporosis International. 2014 ; Vol. 25, No. 8. pp. 1987-1997.
@article{db5f350de4b844dcad634d774cbfa9e5,
title = "A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions",
abstract = "This study aimed to statistically combine multiple health state utility values (HSUVs) reported in the literature for patients with osteoporosis and osteoporotic fractures. Fracture events were associated with decrements in HSUVs which differed between fracture sites. We have provided summary values for use in future health economics analyses in osteoporosis. Osteoporotic fractures have high financial and health burden. Economic evaluations on osteoporotic fracture prevention have been frequently performed in past decades. One of the challenges in the economic evaluations was to identify consistent health state utility values (HSUVs) to use for osteoporotic fracture-related conditions. The objective of this study was to determine summary measures of multiple HSUVs reported in the literature for patients with osteoporosis and osteoporotic fractures. We performed a systematic review, meta-analysis and meta-regression of published literature that reported HSUVs for osteoporotic fracture-related conditions. There were 62 studies representing 142,477 patients included. In total, 362 HSUVs were identified: 106 for pre-fracture; 89 for post-hip fracture; 130 for post-vertebral fracture and 37 for post-wrist fracture. The pooled HSUVs, using a random-effects model were 0.76 (95 {\%} CI 0.75, 0.77, I 2=0.99) for pre-fracture; 0.57 (95 {\%} CI 0.52, 0.63, I 2=1) for post-hip fracture; 0.59 (95 {\%} CI 0.55, 0.62, I 2=0.99) for post-vertebral facture and 0.72 (95 {\%} CI 0.67, 0.78, I 2=1) for post-wrist fracture. Heterogeneities were addressed through meta-regression. HSUVs immediately following hip, vertebral and wrist fractures were 0.31, 0.44 and 0.61, respectively. Patients' HSUVs improved over time following fracture events: HSUVs for the first year after hip, vertebral and wrist fractures were 0.59, 0.55 and 0.78, respectively; and 0.66, 0.66 and 0.81 for subsequent years. Fractures were associated with significant decrements in HSUVs. This study provides a standard set of HSUVs that can be used in health economic assessments in osteoporosis.",
keywords = "Health state utility value, Osteoporosis, Quality of life, Utilities",
author = "L. Si and Winzenberg, {T. M.} and {De Graaff}, B. and Palmer, {A. J.}",
year = "2014",
doi = "10.1007/s00198-014-2636-2",
language = "English",
volume = "25",
pages = "1987--1997",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer, Springer Nature",
number = "8",

}

A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions. / Si, L.; Winzenberg, T. M.; De Graaff, B.; Palmer, A. J.

In: Osteoporosis International, Vol. 25, No. 8, 2014, p. 1987-1997.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - A systematic review and meta-analysis of utility-based quality of life for osteoporosis-related conditions

AU - Si, L.

AU - Winzenberg, T. M.

AU - De Graaff, B.

AU - Palmer, A. J.

PY - 2014

Y1 - 2014

N2 - This study aimed to statistically combine multiple health state utility values (HSUVs) reported in the literature for patients with osteoporosis and osteoporotic fractures. Fracture events were associated with decrements in HSUVs which differed between fracture sites. We have provided summary values for use in future health economics analyses in osteoporosis. Osteoporotic fractures have high financial and health burden. Economic evaluations on osteoporotic fracture prevention have been frequently performed in past decades. One of the challenges in the economic evaluations was to identify consistent health state utility values (HSUVs) to use for osteoporotic fracture-related conditions. The objective of this study was to determine summary measures of multiple HSUVs reported in the literature for patients with osteoporosis and osteoporotic fractures. We performed a systematic review, meta-analysis and meta-regression of published literature that reported HSUVs for osteoporotic fracture-related conditions. There were 62 studies representing 142,477 patients included. In total, 362 HSUVs were identified: 106 for pre-fracture; 89 for post-hip fracture; 130 for post-vertebral fracture and 37 for post-wrist fracture. The pooled HSUVs, using a random-effects model were 0.76 (95 % CI 0.75, 0.77, I 2=0.99) for pre-fracture; 0.57 (95 % CI 0.52, 0.63, I 2=1) for post-hip fracture; 0.59 (95 % CI 0.55, 0.62, I 2=0.99) for post-vertebral facture and 0.72 (95 % CI 0.67, 0.78, I 2=1) for post-wrist fracture. Heterogeneities were addressed through meta-regression. HSUVs immediately following hip, vertebral and wrist fractures were 0.31, 0.44 and 0.61, respectively. Patients' HSUVs improved over time following fracture events: HSUVs for the first year after hip, vertebral and wrist fractures were 0.59, 0.55 and 0.78, respectively; and 0.66, 0.66 and 0.81 for subsequent years. Fractures were associated with significant decrements in HSUVs. This study provides a standard set of HSUVs that can be used in health economic assessments in osteoporosis.

AB - This study aimed to statistically combine multiple health state utility values (HSUVs) reported in the literature for patients with osteoporosis and osteoporotic fractures. Fracture events were associated with decrements in HSUVs which differed between fracture sites. We have provided summary values for use in future health economics analyses in osteoporosis. Osteoporotic fractures have high financial and health burden. Economic evaluations on osteoporotic fracture prevention have been frequently performed in past decades. One of the challenges in the economic evaluations was to identify consistent health state utility values (HSUVs) to use for osteoporotic fracture-related conditions. The objective of this study was to determine summary measures of multiple HSUVs reported in the literature for patients with osteoporosis and osteoporotic fractures. We performed a systematic review, meta-analysis and meta-regression of published literature that reported HSUVs for osteoporotic fracture-related conditions. There were 62 studies representing 142,477 patients included. In total, 362 HSUVs were identified: 106 for pre-fracture; 89 for post-hip fracture; 130 for post-vertebral fracture and 37 for post-wrist fracture. The pooled HSUVs, using a random-effects model were 0.76 (95 % CI 0.75, 0.77, I 2=0.99) for pre-fracture; 0.57 (95 % CI 0.52, 0.63, I 2=1) for post-hip fracture; 0.59 (95 % CI 0.55, 0.62, I 2=0.99) for post-vertebral facture and 0.72 (95 % CI 0.67, 0.78, I 2=1) for post-wrist fracture. Heterogeneities were addressed through meta-regression. HSUVs immediately following hip, vertebral and wrist fractures were 0.31, 0.44 and 0.61, respectively. Patients' HSUVs improved over time following fracture events: HSUVs for the first year after hip, vertebral and wrist fractures were 0.59, 0.55 and 0.78, respectively; and 0.66, 0.66 and 0.81 for subsequent years. Fractures were associated with significant decrements in HSUVs. This study provides a standard set of HSUVs that can be used in health economic assessments in osteoporosis.

KW - Health state utility value

KW - Osteoporosis

KW - Quality of life

KW - Utilities

UR - http://www.scopus.com/inward/record.url?scp=84904409572&partnerID=8YFLogxK

U2 - 10.1007/s00198-014-2636-2

DO - 10.1007/s00198-014-2636-2

M3 - Review article

VL - 25

SP - 1987

EP - 1997

JO - Osteoporosis International

T2 - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 8

ER -