A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study

Anna Conway; Heather Valerio; Maryam Alavi; David Silk; Carla Treloar; Behzad Hajarizadeh; Alison D. Marshall; Marianne Martinello; Andrew Milat; Adrian Dunlop; Carolyn Murray; Bianca Prain; Charles Henderson; Janaki Amin; Phillip Read; Pip Marks; Louisa Degenhardt; Jeremy Hayllar; David Reid; Carla Gorton; Thao Lam; Michael Christmass; Alexandra Wade; Mark Montebello; Gregory J. Dore; Jason Grebely; ETHOS Engage Study Group

doi:10.3390/v14071555

A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study

Anna Conway, Heather Valerio, Maryam Alavi, David Silk, Carla Treloar, Behzad Hajarizadeh, Alison D. Marshall, Marianne Martinello, Andrew Milat, Adrian Dunlop, Carolyn Murray, Bianca Prain, Charles Henderson, Janaki Amin, Phillip Read, Pip Marks, Louisa Degenhardt, Jeremy Hayllar, David Reid, Carla GortonThao Lam, Michael Christmass, Alexandra Wade, Mark Montebello, Gregory J. Dore, Jason Grebely, ETHOS Engage Study Group

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Abstract

This study evaluated HCV treatment initiation among people who inject drugs (PWID) following an intervention of campaign days involving peer connection, point-of-care HCV RNA testing, and linkage to nursing support. ETHOS Engage is an observational cohort study of PWID attending 25 drug treatment clinics and needle and syringe programs in Australia (May 2018-September 2019). Point-of-care results were provided to the nurse, facilitating confirmatory testing and treatment. The study aimed to evaluate treatment uptake and factors associated with treatment at 24 months post-enrolment. There were 317 people with current HCV infection and eligible for treatment (median age 43, 65% male, 15% homeless, 69% receiving opioid agonist treatment, 70% injected in last month). Overall, 15% (47/317), 27% (85/317), 38% (120/317), and 49% (155/317) of people with current HCV infection had initiated treatment at 3-, 6-, 12-, and 24-months following testing, respectively. Homelessness (adjusted hazard ratio (aHR): 0.40; 95% confidence interval: 0.23, 0.71) and incarceration in the past 12 months (vs. never, aHR:0.46; 0.28, 0.76) were associated with decreased treatment initiation in the 24 months post-enrolment. This testing campaign intervention facilitated HCV treatment uptake among PWID. Further interventions are needed to achieve HCV elimination among people experiencing homelessness or incarceration.

Original language	English
Article number	1555
Pages (from-to)	1-15
Number of pages	15
Journal	Viruses
Volume	14
Issue number	7
DOIs	https://doi.org/10.3390/v14071555
Publication status	Published - 16 Jul 2022

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

direct-acting antiviral era
Hepatitis C virus elimination
Hepatitis C virus infection
Hepatitis C virus treatment
people who inject drugs

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Conway, A., Valerio, H., Alavi, M., Silk, D., Treloar, C., Hajarizadeh, B., Marshall, A. D., Martinello, M., Milat, A., Dunlop, A., Murray, C., Prain, B., Henderson, C., Amin, J., Read, P., Marks, P., Degenhardt, L., Hayllar, J., Reid, D., ... ETHOS Engage Study Group (2022). A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study. Viruses, 14(7), 1-15. Article 1555. https://doi.org/10.3390/v14071555

@article{70182841714b4488b6f892de3280a5a1,

title = "A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study",

abstract = "This study evaluated HCV treatment initiation among people who inject drugs (PWID) following an intervention of campaign days involving peer connection, point-of-care HCV RNA testing, and linkage to nursing support. ETHOS Engage is an observational cohort study of PWID attending 25 drug treatment clinics and needle and syringe programs in Australia (May 2018-September 2019). Point-of-care results were provided to the nurse, facilitating confirmatory testing and treatment. The study aimed to evaluate treatment uptake and factors associated with treatment at 24 months post-enrolment. There were 317 people with current HCV infection and eligible for treatment (median age 43, 65% male, 15% homeless, 69% receiving opioid agonist treatment, 70% injected in last month). Overall, 15% (47/317), 27% (85/317), 38% (120/317), and 49% (155/317) of people with current HCV infection had initiated treatment at 3-, 6-, 12-, and 24-months following testing, respectively. Homelessness (adjusted hazard ratio (aHR): 0.40; 95% confidence interval: 0.23, 0.71) and incarceration in the past 12 months (vs. never, aHR:0.46; 0.28, 0.76) were associated with decreased treatment initiation in the 24 months post-enrolment. This testing campaign intervention facilitated HCV treatment uptake among PWID. Further interventions are needed to achieve HCV elimination among people experiencing homelessness or incarceration.",

keywords = "direct-acting antiviral era, Hepatitis C virus elimination, Hepatitis C virus infection, Hepatitis C virus treatment, people who inject drugs",

author = "Anna Conway and Heather Valerio and Maryam Alavi and David Silk and Carla Treloar and Behzad Hajarizadeh and Marshall, {Alison D.} and Marianne Martinello and Andrew Milat and Adrian Dunlop and Carolyn Murray and Bianca Prain and Charles Henderson and Janaki Amin and Phillip Read and Pip Marks and Louisa Degenhardt and Jeremy Hayllar and David Reid and Carla Gorton and Thao Lam and Michael Christmass and Alexandra Wade and Mark Montebello and Dore, {Gregory J.} and Jason Grebely and {ETHOS Engage Study Group}",

note = "Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2022",

month = jul,

day = "16",

doi = "10.3390/v14071555",

language = "English",

volume = "14",

pages = "1--15",

journal = "Viruses",

issn = "1999-4915",

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number = "7",

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Conway, A, Valerio, H, Alavi, M, Silk, D, Treloar, C, Hajarizadeh, B, Marshall, AD, Martinello, M, Milat, A, Dunlop, A, Murray, C, Prain, B, Henderson, C, Amin, J, Read, P, Marks, P, Degenhardt, L, Hayllar, J, Reid, D, Gorton, C, Lam, T, Christmass, M, Wade, A, Montebello, M, Dore, GJ, Grebely, J & ETHOS Engage Study Group 2022, 'A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study', Viruses, vol. 14, no. 7, 1555, pp. 1-15. https://doi.org/10.3390/v14071555

A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study. / Conway, Anna; Valerio, Heather; Alavi, Maryam et al.
In: Viruses, Vol. 14, No. 7, 1555, 16.07.2022, p. 1-15.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs

T2 - the ETHOS Engage study

AU - Conway, Anna

AU - Valerio, Heather

AU - Alavi, Maryam

AU - Silk, David

AU - Treloar, Carla

AU - Hajarizadeh, Behzad

AU - Marshall, Alison D.

AU - Martinello, Marianne

AU - Milat, Andrew

AU - Dunlop, Adrian

AU - Murray, Carolyn

AU - Prain, Bianca

AU - Henderson, Charles

AU - Amin, Janaki

AU - Read, Phillip

AU - Marks, Pip

AU - Degenhardt, Louisa

AU - Hayllar, Jeremy

AU - Reid, David

AU - Gorton, Carla

AU - Lam, Thao

AU - Christmass, Michael

AU - Wade, Alexandra

AU - Montebello, Mark

AU - Dore, Gregory J.

AU - Grebely, Jason

AU - ETHOS Engage Study Group

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2022/7/16

Y1 - 2022/7/16

N2 - This study evaluated HCV treatment initiation among people who inject drugs (PWID) following an intervention of campaign days involving peer connection, point-of-care HCV RNA testing, and linkage to nursing support. ETHOS Engage is an observational cohort study of PWID attending 25 drug treatment clinics and needle and syringe programs in Australia (May 2018-September 2019). Point-of-care results were provided to the nurse, facilitating confirmatory testing and treatment. The study aimed to evaluate treatment uptake and factors associated with treatment at 24 months post-enrolment. There were 317 people with current HCV infection and eligible for treatment (median age 43, 65% male, 15% homeless, 69% receiving opioid agonist treatment, 70% injected in last month). Overall, 15% (47/317), 27% (85/317), 38% (120/317), and 49% (155/317) of people with current HCV infection had initiated treatment at 3-, 6-, 12-, and 24-months following testing, respectively. Homelessness (adjusted hazard ratio (aHR): 0.40; 95% confidence interval: 0.23, 0.71) and incarceration in the past 12 months (vs. never, aHR:0.46; 0.28, 0.76) were associated with decreased treatment initiation in the 24 months post-enrolment. This testing campaign intervention facilitated HCV treatment uptake among PWID. Further interventions are needed to achieve HCV elimination among people experiencing homelessness or incarceration.

AB - This study evaluated HCV treatment initiation among people who inject drugs (PWID) following an intervention of campaign days involving peer connection, point-of-care HCV RNA testing, and linkage to nursing support. ETHOS Engage is an observational cohort study of PWID attending 25 drug treatment clinics and needle and syringe programs in Australia (May 2018-September 2019). Point-of-care results were provided to the nurse, facilitating confirmatory testing and treatment. The study aimed to evaluate treatment uptake and factors associated with treatment at 24 months post-enrolment. There were 317 people with current HCV infection and eligible for treatment (median age 43, 65% male, 15% homeless, 69% receiving opioid agonist treatment, 70% injected in last month). Overall, 15% (47/317), 27% (85/317), 38% (120/317), and 49% (155/317) of people with current HCV infection had initiated treatment at 3-, 6-, 12-, and 24-months following testing, respectively. Homelessness (adjusted hazard ratio (aHR): 0.40; 95% confidence interval: 0.23, 0.71) and incarceration in the past 12 months (vs. never, aHR:0.46; 0.28, 0.76) were associated with decreased treatment initiation in the 24 months post-enrolment. This testing campaign intervention facilitated HCV treatment uptake among PWID. Further interventions are needed to achieve HCV elimination among people experiencing homelessness or incarceration.

KW - direct-acting antiviral era

KW - Hepatitis C virus elimination

KW - Hepatitis C virus infection

KW - Hepatitis C virus treatment

KW - people who inject drugs

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U2 - 10.3390/v14071555

DO - 10.3390/v14071555

M3 - Article

C2 - 35891535

AN - SCOPUS:85135137803

SN - 1999-4915

VL - 14

SP - 1

EP - 15

JO - Viruses

JF - Viruses

IS - 7

M1 - 1555

ER -

A testing campaign intervention consisting of peer-facilitated engagement, point-of-care HCV RNA testing, and linkage to nursing support to enhance Hepatitis C treatment uptake among people who inject drugs: the ETHOS Engage study

Abstract

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Keywords

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