A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Kartika Wardhani; Aviva Levina; Biyun Sun; Georges E. R. Grau; F. Richard Keene; J. Grant Collins; Peter A. Lay

doi:10.1039/d2cc05827h

A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Kartika Wardhani, Aviva Levina, Biyun Sun, Georges E. R. Grau, F. Richard Keene, J. Grant Collins, Peter A. Lay^*

^*Corresponding author for this work

Dementia Research Centre

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

Original language	English
Pages (from-to)	6877-6880
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	45
Early online date	10 May 2023
DOIs	https://doi.org/10.1039/d2cc05827h
Publication status	Published - 1 Jun 2023

Access to Document

10.1039/d2cc05827h

Cite this

@article{3f233307460a4e049eac1239eb81f6db,

title = "A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium",

abstract = "A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.",

author = "Kartika Wardhani and Aviva Levina and Biyun Sun and Grau, {Georges E. R.} and Keene, {F. Richard} and Collins, {J. Grant} and Lay, {Peter A.}",

year = "2023",

month = jun,

day = "1",

doi = "10.1039/d2cc05827h",

language = "English",

volume = "59",

pages = "6877--6880",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "45",

}

TY - JOUR

T1 - A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

AU - Wardhani, Kartika

AU - Levina, Aviva

AU - Sun, Biyun

AU - Grau, Georges E. R.

AU - Keene, F. Richard

AU - Collins, J. Grant

AU - Lay, Peter A.

PY - 2023/6/1

Y1 - 2023/6/1

N2 - A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

AB - A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

UR - http://www.scopus.com/inward/record.url?scp=85160422277&partnerID=8YFLogxK

U2 - 10.1039/d2cc05827h

DO - 10.1039/d2cc05827h

M3 - Article

C2 - 37195631

AN - SCOPUS:85160422277

SN - 1359-7345

VL - 59

SP - 6877

EP - 6880

JO - Chemical Communications

JF - Chemical Communications

IS - 45

ER -

A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Abstract

Access to Document

Other files and links

Fingerprint

Cite this