A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Kartika Wardhani; Aviva Levina; Biyun Sun; Georges E. R. Grau; F. Richard Keene; J. Grant Collins; Peter A. Lay

doi:10.1039/d2cc05827h

A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Kartika Wardhani, Aviva Levina, Biyun Sun, Georges E. R. Grau, F. Richard Keene, J. Grant Collins, Peter A. Lay^*

^*Corresponding author for this work

Dementia Research Centre

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

Original language	English
Pages (from-to)	6877-6880
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	45
Early online date	10 May 2023
DOIs	https://doi.org/10.1039/d2cc05827h
Publication status	Published - 1 Jun 2023

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abstract = "A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.",

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AU - Wardhani, Kartika

AU - Levina, Aviva

AU - Sun, Biyun

AU - Grau, Georges E. R.

AU - Keene, F. Richard

AU - Collins, J. Grant

AU - Lay, Peter A.

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AB - A new photoluminescent polypyridylruthenium(ii) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.

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ER -

A tetranuclear polypyridylruthenium(ii) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Abstract

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