A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease

Emily K. Don*, Isabel Formella, Andrew P. Badrock, Thomas E. Hall, Marco Morsch, Elinor Hortle, Alison Hogan, Sharron Chow, Serene S. L. Gwee, Jack J. Stoddart, Garth Nicholson, Roger Chung, Nicholas J. Cole

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalZebrafish
Volume14
Issue number1
Early online date15 Sep 2016
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • disease model
  • neurodegenerative disease
  • Tol2 gateway
  • transgenesis

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