Abstract
Assuring biologics safety is a key challenge for modern pharmaceutical industry, especially in developing countries. This paper reports a microfluidic platform for rapid biologics assessment via drugreceptor binding assays. Molecular charge modulation and electrokinetic concentration (MCM-EC) was proposed as a generic and versatile approach for realizing immobilization-free drug-receptor binding assays. Human growth hormone was tested as a model biologics, and its activity and stability shift has been correlated with the outcome of MCM-EC assay.
| Original language | English |
|---|---|
| Title of host publication | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015) |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 928-930 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780979806483 |
| ISBN (Print) | 9781510817876 |
| Publication status | Published - 2015 |
| Externally published | Yes |
| Event | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: 25 Oct 2015 → 29 Oct 2015 |
Other
| Other | 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 |
|---|---|
| Country/Territory | Korea, Republic of |
| City | Gyeongju |
| Period | 25/10/15 → 29/10/15 |
Keywords
- Binding assay
- Biologics analysis
- Molecular charge modulation