A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays

Wei Ouyang; Sung Hee Ko; Annie Yu Wang; William Hancock; Jongyoon Han

A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays

Wei Ouyang, Sung Hee Ko, Annie Yu Wang, William Hancock, Jongyoon Han^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

1 Citation (Scopus)

Abstract

Assuring biologics safety is a key challenge for modern pharmaceutical industry, especially in developing countries. This paper reports a microfluidic platform for rapid biologics assessment via drugreceptor binding assays. Molecular charge modulation and electrokinetic concentration (MCM-EC) was proposed as a generic and versatile approach for realizing immobilization-free drug-receptor binding assays. Human growth hormone was tested as a model biologics, and its activity and stability shift has been correlated with the outcome of MCM-EC assay.

Original language	English
Title of host publication	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)
Publisher	Chemical and Biological Microsystems Society
Pages	928-930
Number of pages	3
ISBN (Electronic)	9780979806483
ISBN (Print)	9781510817876
Publication status	Published - 2015
Externally published	Yes
Event	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of Duration: 25 Oct 2015 → 29 Oct 2015

Other

Other	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Country/Territory	Korea, Republic of
City	Gyeongju
Period	25/10/15 → 29/10/15

Keywords

Binding assay
Biologics analysis
Molecular charge modulation

Cite this

@inproceedings{1e124ec113dc46c788512fa19b3a484c,

title = "A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays",

abstract = "Assuring biologics safety is a key challenge for modern pharmaceutical industry, especially in developing countries. This paper reports a microfluidic platform for rapid biologics assessment via drugreceptor binding assays. Molecular charge modulation and electrokinetic concentration (MCM-EC) was proposed as a generic and versatile approach for realizing immobilization-free drug-receptor binding assays. Human growth hormone was tested as a model biologics, and its activity and stability shift has been correlated with the outcome of MCM-EC assay.",

keywords = "Binding assay, Biologics analysis, Molecular charge modulation",

author = "Wei Ouyang and Ko, \{Sung Hee\} and Wang, \{Annie Yu\} and William Hancock and Jongyoon Han",

year = "2015",

language = "English",

isbn = "9781510817876",

pages = "928--930",

booktitle = "19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)",

publisher = "Chemical and Biological Microsystems Society",

note = "19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",

}

Ouyang, W, Ko, SH, Wang, AY, Hancock, W & Han, J 2015, A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays. in 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Chemical and Biological Microsystems Society, pp. 928-930, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, Gyeongju, Korea, Republic of, 25/10/15.

A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays. / Ouyang, Wei; Ko, Sung Hee; Wang, Annie Yu et al.
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Chemical and Biological Microsystems Society, 2015. p. 928-930.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays

AU - Ouyang, Wei

AU - Ko, Sung Hee

AU - Wang, Annie Yu

AU - Hancock, William

AU - Han, Jongyoon

PY - 2015

Y1 - 2015

N2 - Assuring biologics safety is a key challenge for modern pharmaceutical industry, especially in developing countries. This paper reports a microfluidic platform for rapid biologics assessment via drugreceptor binding assays. Molecular charge modulation and electrokinetic concentration (MCM-EC) was proposed as a generic and versatile approach for realizing immobilization-free drug-receptor binding assays. Human growth hormone was tested as a model biologics, and its activity and stability shift has been correlated with the outcome of MCM-EC assay.

AB - Assuring biologics safety is a key challenge for modern pharmaceutical industry, especially in developing countries. This paper reports a microfluidic platform for rapid biologics assessment via drugreceptor binding assays. Molecular charge modulation and electrokinetic concentration (MCM-EC) was proposed as a generic and versatile approach for realizing immobilization-free drug-receptor binding assays. Human growth hormone was tested as a model biologics, and its activity and stability shift has been correlated with the outcome of MCM-EC assay.

KW - Binding assay

KW - Biologics analysis

KW - Molecular charge modulation

UR - https://www.scopus.com/pages/publications/84983364725

M3 - Conference proceeding contribution

AN - SCOPUS:84983364725

SN - 9781510817876

SP - 928

EP - 930

BT - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015)

PB - Chemical and Biological Microsystems Society

T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015

Y2 - 25 October 2015 through 29 October 2015

ER -

A versatile platform for rapid biologics activity assessment via microfluidic drug-receptor binding assays

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