TY - UNPB
T1 - AadT, a new weapon in Acinetobacter’s fight against antibiotics
AU - Naidu, Varsha
AU - Shah, Bhumika
AU - Maher, Claire
AU - Paulsen, Ian T.
AU - Hassan, Karl A.
PY - 2023/4/25
Y1 - 2023/4/25
N2 - A novel multidrug efflux pump, AadT from the Drug:H+ antiporter 2 family, was discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the antimicrobial resistance potential and examined the distribution of this gene. Putative homologs of this efflux pump were encoded in many Acinetobacter species and other Gram-negative species, and were genetically associated with novel variants of adeAB(C), which encodes a major tripartite efflux pump in Acinetobacter. The AadT pump conferred decreased susceptibility to at least eight diverse antimicrobials, including antibiotics erythromycin, tetracycline; biocides chlorhexidine; and dyes ethidium bromide and DAPI. These results show that AadT is a new determinant in the Acinetobacter resistance arsenal and may cooperate with variants of AdeAB(C).
AB - A novel multidrug efflux pump, AadT from the Drug:H+ antiporter 2 family, was discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the antimicrobial resistance potential and examined the distribution of this gene. Putative homologs of this efflux pump were encoded in many Acinetobacter species and other Gram-negative species, and were genetically associated with novel variants of adeAB(C), which encodes a major tripartite efflux pump in Acinetobacter. The AadT pump conferred decreased susceptibility to at least eight diverse antimicrobials, including antibiotics erythromycin, tetracycline; biocides chlorhexidine; and dyes ethidium bromide and DAPI. These results show that AadT is a new determinant in the Acinetobacter resistance arsenal and may cooperate with variants of AdeAB(C).
U2 - 10.1101/2023.01.03.522653
DO - 10.1101/2023.01.03.522653
M3 - Preprint
T3 - bioRxiv
BT - AadT, a new weapon in Acinetobacter’s fight against antibiotics
ER -