AadT, a new weapon in Acinetobacter's fight against antibiotics

Varsha Naidu, Bhumika Shah, Claire Maher, Ian T. Paulsen, Karl A. Hassan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
21 Downloads (Pure)

Abstract

Genes encoding a novel multidrug efflux pump, AadT, from the Drug:H+ antiporter 2 family, were discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the antimicrobial resistance potential, and examined the distribution of these genes. aadT homologs were found in many Acinetobacter and other Gram-negative species and were typically adjacent to novel variants of adeAB(C), which encodes a major tripartite efflux pump in Acinetobacter. The AadT pump decreased bacterial susceptibility to at least eight diverse antimicrobials, including antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. These results show that AadT is a multidrug efflux pump in the Acinetobacter resistance arsenal and may cooperate with variants of AdeAB(C).
Original languageEnglish
Article number001341
Pages (from-to)1-6
Number of pages6
JournalMicrobiology
Volume169
Issue number5
Early online date30 May 2023
DOIs
Publication statusPublished - 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Acinetobacter baumannii
  • Acinetobacter plasmids
  • Antimicrobial Resistance
  • efflux pumps
  • Major Facilitator Superfamily (MFS)
  • RND efflux

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