From the deep: The title actinomycete yielded three new abyssomicins J-L. The dimeric thioether J (see scheme) represents a unique example of a masked Michael acceptor with anti-TB properties. Mechanistic insights into the biosynthesis, biomimetic synthesis, stability, and biological mechanism of action of abyssomicins aid our understanding of, and prospects for the development of Michael-acceptor-based drugs.
- natural products
- structure elucidation