Academic productivity of young people with allergic rhinitis: a MASK-air study

Rafael José Vieira; Nhân Pham-Thi; Josep M. Anto; Wienczyslawa Czarlewski; Ana Sá-Sousa; Rita Amaral; Anna Bedbrook; Sinthia Bosnic-Anticevich; Luisa Brussino; G. Walter Canonica; Lorenzo Cecchi; Alvaro A. Cruz; Wytske J. Fokkens; Bilun Gemicioglu; Tari Haahtela; Juan Carlos Ivancevich; Ludger Klimek; Piotr Kuna; Violeta Kvedariene; Désirée Larenas-Linnemann; Mario Morais-Almeida; Joaquim Mullol; Marek Niedoszytko; Yoshitaka Okamoto; Nikolaos G. Papadopoulos; Vincenzo Patella; Oliver Pfaar; Frederico S. Regateiro; Sietze Reitsma; Philip W. Rouadi; Boleslaw Samolinski; Aziz Sheikh; Luis Taborda-Barata; Sanna Toppila-Salmi; Joaquin Sastre; Ionna Tsiligianni; Arunas Valiulis; Maria Teresa Ventura; Susan Waserman; Arzu Yorgancioglu; Mihaela Zidarn; Torsten Zuberbier; João A. Fonseca; Jean Bousquet; Bernardo Sousa-Pinto; MASK study group

doi:10.1016/j.jaip.2022.08.015

Academic productivity of young people with allergic rhinitis: a MASK-air study

Rafael José Vieira, Nhân Pham-Thi, Josep M. Anto, Wienczyslawa Czarlewski, Ana Sá-Sousa, Rita Amaral, Anna Bedbrook, Sinthia Bosnic-Anticevich, Luisa Brussino, G. Walter Canonica, Lorenzo Cecchi, Alvaro A. Cruz, Wytske J. Fokkens, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Ludger Klimek, Piotr Kuna, Violeta Kvedariene, Désirée Larenas-LinnemannMario Morais-Almeida, Joaquim Mullol, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Vincenzo Patella, Oliver Pfaar, Frederico S. Regateiro, Sietze Reitsma, Philip W. Rouadi, Boleslaw Samolinski, Aziz Sheikh, Luis Taborda-Barata, Sanna Toppila-Salmi, Joaquin Sastre, Ionna Tsiligianni, Arunas Valiulis, Maria Teresa Ventura, Susan Waserman, Arzu Yorgancioglu, Mihaela Zidarn, Torsten Zuberbier, João A. Fonseca, Jean Bousquet, Bernardo Sousa-Pinto, MASK study group

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background: Several studies have suggested an impact of allergic rhinitis on academic productivity. However, large studies with real-world data (RWD) are not available.

Objective: To use RWD to assess the impact of allergic rhinitis on academic performance (measured through a visual analog scale [VAS] education and the Work Productivity and Activity Impairment Questionnaire plus Classroom Impairment Questions: Allergy Specific [WPAI+CIQ:AS] questionnaire), and to identify factors associated with the impact of allergic rhinitis on academic performance.

Methods: We assessed data from the MASK-air mHealth app of users aged 13 to 29 years with allergic rhinitis. We assessed the correlation between variables measuring the impact of allergies on academic performance (VAS education, WPAI+CIQ:AS impact of allergy symptoms on academic performance, and WPAI+CIQ:AS percentage of education hours lost due to allergies) and other variables. In addition, we identified factors associated with the impact of allergic symptoms on academic productivity through multivariable mixed models.

Results: A total of 13,454 days (from 1970 patients) were studied. VAS education was strongly correlated with the WPAI+CIQ:AS impact of allergy symptoms on academic productivity (Spearman correlation coefficient = 0.71 [95% confidence interval (CI) = 0.58; 0.80]), VAS global allergy symptoms (0.70 [95% CI = 0.68; 0.71]), and VAS nose (0.66 [95% CI = 0.65; 0.68]). In multivariable regression models, immunotherapy showed a strong negative association with VAS education (regression coefficient = −2.32 [95% CI = −4.04; −0.59]). Poor rhinitis control, measured by the combined symptom-medication score, was associated with worse VAS education (regression coefficient = 0.88 [95% CI = 0.88; 0.92]), higher impact on academic productivity (regression coefficient = 0.69 [95% CI = 0.49; 0.90]), and higher percentage of missed education hours due to allergy (regression coefficient = 0.44 [95% CI = 0.25; 0.63]).

Conclusion: Allergy symptoms and worse rhinitis control are associated with worse academic productivity, whereas immunotherapy is associated with higher productivity.

Original language	English
Pages (from-to)	3008-3017.e4
Number of pages	14
Journal	Journal of Allergy and Clinical Immunology: In Practice
Volume	10
Issue number	11
Early online date	20 Aug 2022
DOIs	https://doi.org/10.1016/j.jaip.2022.08.015
Publication status	Published - Nov 2022
Externally published	Yes

Keywords

Allergic rhinitis
MASK
Real-world data
Mobile health
Academic productivity

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10.1016/j.jaip.2022.08.015

Cite this

Vieira, R. J., Pham-Thi, N., Anto, J. M., Czarlewski, W., Sá-Sousa, A., Amaral, R., Bedbrook, A., Bosnic-Anticevich, S., Brussino, L., Canonica, G. W., Cecchi, L., Cruz, A. A., Fokkens, W. J., Gemicioglu, B., Haahtela, T., Ivancevich, J. C., Klimek, L., Kuna, P., Kvedariene, V., ... MASK study group (2022). Academic productivity of young people with allergic rhinitis: a MASK-air study. Journal of Allergy and Clinical Immunology: In Practice, 10(11), 3008-3017.e4. https://doi.org/10.1016/j.jaip.2022.08.015

@article{6495a0982294457cae06e219cae57e92,

title = "Academic productivity of young people with allergic rhinitis: a MASK-air study",

abstract = "Background: Several studies have suggested an impact of allergic rhinitis on academic productivity. However, large studies with real-world data (RWD) are not available.Objective: To use RWD to assess the impact of allergic rhinitis on academic performance (measured through a visual analog scale [VAS] education and the Work Productivity and Activity Impairment Questionnaire plus Classroom Impairment Questions: Allergy Specific [WPAI+CIQ:AS] questionnaire), and to identify factors associated with the impact of allergic rhinitis on academic performance.Methods: We assessed data from the MASK-air mHealth app of users aged 13 to 29 years with allergic rhinitis. We assessed the correlation between variables measuring the impact of allergies on academic performance (VAS education, WPAI+CIQ:AS impact of allergy symptoms on academic performance, and WPAI+CIQ:AS percentage of education hours lost due to allergies) and other variables. In addition, we identified factors associated with the impact of allergic symptoms on academic productivity through multivariable mixed models.Results: A total of 13,454 days (from 1970 patients) were studied. VAS education was strongly correlated with the WPAI+CIQ:AS impact of allergy symptoms on academic productivity (Spearman correlation coefficient = 0.71 [95% confidence interval (CI) = 0.58; 0.80]), VAS global allergy symptoms (0.70 [95% CI = 0.68; 0.71]), and VAS nose (0.66 [95% CI = 0.65; 0.68]). In multivariable regression models, immunotherapy showed a strong negative association with VAS education (regression coefficient = −2.32 [95% CI = −4.04; −0.59]). Poor rhinitis control, measured by the combined symptom-medication score, was associated with worse VAS education (regression coefficient = 0.88 [95% CI = 0.88; 0.92]), higher impact on academic productivity (regression coefficient = 0.69 [95% CI = 0.49; 0.90]), and higher percentage of missed education hours due to allergy (regression coefficient = 0.44 [95% CI = 0.25; 0.63]).Conclusion: Allergy symptoms and worse rhinitis control are associated with worse academic productivity, whereas immunotherapy is associated with higher productivity.",

keywords = "Allergic rhinitis, MASK, Real-world data, Mobile health, Academic productivity",

author = "Vieira, {Rafael Jos{\'e}} and Nh{\^a}n Pham-Thi and Anto, {Josep M.} and Wienczyslawa Czarlewski and Ana S{\'a}-Sousa and Rita Amaral and Anna Bedbrook and Sinthia Bosnic-Anticevich and Luisa Brussino and Canonica, {G. Walter} and Lorenzo Cecchi and Cruz, {Alvaro A.} and Fokkens, {Wytske J.} and Bilun Gemicioglu and Tari Haahtela and Ivancevich, {Juan Carlos} and Ludger Klimek and Piotr Kuna and Violeta Kvedariene and D{\'e}sir{\'e}e Larenas-Linnemann and Mario Morais-Almeida and Joaquim Mullol and Marek Niedoszytko and Yoshitaka Okamoto and Papadopoulos, {Nikolaos G.} and Vincenzo Patella and Oliver Pfaar and Regateiro, {Frederico S.} and Sietze Reitsma and Rouadi, {Philip W.} and Boleslaw Samolinski and Aziz Sheikh and Luis Taborda-Barata and Sanna Toppila-Salmi and Joaquin Sastre and Ionna Tsiligianni and Arunas Valiulis and Ventura, {Maria Teresa} and Susan Waserman and Arzu Yorgancioglu and Mihaela Zidarn and Torsten Zuberbier and Fonseca, {Jo{\~a}o A.} and Jean Bousquet and Bernardo Sousa-Pinto and {MASK study group}",

year = "2022",

month = nov,

doi = "10.1016/j.jaip.2022.08.015",

language = "English",

volume = "10",

pages = "3008--3017.e4",

journal = "Journal of Allergy and Clinical Immunology: In Practice",

issn = "2213-2198",

publisher = "Elsevier",

number = "11",

}

Vieira, RJ, Pham-Thi, N, Anto, JM, Czarlewski, W, Sá-Sousa, A, Amaral, R, Bedbrook, A, Bosnic-Anticevich, S, Brussino, L, Canonica, GW, Cecchi, L, Cruz, AA, Fokkens, WJ, Gemicioglu, B, Haahtela, T, Ivancevich, JC, Klimek, L, Kuna, P, Kvedariene, V, Larenas-Linnemann, D, Morais-Almeida, M, Mullol, J, Niedoszytko, M, Okamoto, Y, Papadopoulos, NG, Patella, V, Pfaar, O, Regateiro, FS, Reitsma, S, Rouadi, PW, Samolinski, B, Sheikh, A, Taborda-Barata, L, Toppila-Salmi, S, Sastre, J, Tsiligianni, I, Valiulis, A, Ventura, MT, Waserman, S, Yorgancioglu, A, Zidarn, M, Zuberbier, T, Fonseca, JA, Bousquet, J, Sousa-Pinto, B & MASK study group 2022, 'Academic productivity of young people with allergic rhinitis: a MASK-air study', Journal of Allergy and Clinical Immunology: In Practice, vol. 10, no. 11, pp. 3008-3017.e4. https://doi.org/10.1016/j.jaip.2022.08.015

TY - JOUR

T1 - Academic productivity of young people with allergic rhinitis

T2 - a MASK-air study

AU - Vieira, Rafael José

AU - Pham-Thi, Nhân

AU - Anto, Josep M.

AU - Czarlewski, Wienczyslawa

AU - Sá-Sousa, Ana

AU - Amaral, Rita

AU - Bedbrook, Anna

AU - Bosnic-Anticevich, Sinthia

AU - Brussino, Luisa

AU - Canonica, G. Walter

AU - Cecchi, Lorenzo

AU - Cruz, Alvaro A.

AU - Fokkens, Wytske J.

AU - Gemicioglu, Bilun

AU - Haahtela, Tari

AU - Ivancevich, Juan Carlos

AU - Klimek, Ludger

AU - Kuna, Piotr

AU - Kvedariene, Violeta

AU - Larenas-Linnemann, Désirée

AU - Morais-Almeida, Mario

AU - Mullol, Joaquim

AU - Niedoszytko, Marek

AU - Okamoto, Yoshitaka

AU - Papadopoulos, Nikolaos G.

AU - Patella, Vincenzo

AU - Pfaar, Oliver

AU - Regateiro, Frederico S.

AU - Reitsma, Sietze

AU - Rouadi, Philip W.

AU - Samolinski, Boleslaw

AU - Sheikh, Aziz

AU - Taborda-Barata, Luis

AU - Toppila-Salmi, Sanna

AU - Sastre, Joaquin

AU - Tsiligianni, Ionna

AU - Valiulis, Arunas

AU - Ventura, Maria Teresa

AU - Waserman, Susan

AU - Yorgancioglu, Arzu

AU - Zidarn, Mihaela

AU - Zuberbier, Torsten

AU - Fonseca, João A.

AU - Bousquet, Jean

AU - Sousa-Pinto, Bernardo

AU - MASK study group

PY - 2022/11

Y1 - 2022/11

N2 - Background: Several studies have suggested an impact of allergic rhinitis on academic productivity. However, large studies with real-world data (RWD) are not available.Objective: To use RWD to assess the impact of allergic rhinitis on academic performance (measured through a visual analog scale [VAS] education and the Work Productivity and Activity Impairment Questionnaire plus Classroom Impairment Questions: Allergy Specific [WPAI+CIQ:AS] questionnaire), and to identify factors associated with the impact of allergic rhinitis on academic performance.Methods: We assessed data from the MASK-air mHealth app of users aged 13 to 29 years with allergic rhinitis. We assessed the correlation between variables measuring the impact of allergies on academic performance (VAS education, WPAI+CIQ:AS impact of allergy symptoms on academic performance, and WPAI+CIQ:AS percentage of education hours lost due to allergies) and other variables. In addition, we identified factors associated with the impact of allergic symptoms on academic productivity through multivariable mixed models.Results: A total of 13,454 days (from 1970 patients) were studied. VAS education was strongly correlated with the WPAI+CIQ:AS impact of allergy symptoms on academic productivity (Spearman correlation coefficient = 0.71 [95% confidence interval (CI) = 0.58; 0.80]), VAS global allergy symptoms (0.70 [95% CI = 0.68; 0.71]), and VAS nose (0.66 [95% CI = 0.65; 0.68]). In multivariable regression models, immunotherapy showed a strong negative association with VAS education (regression coefficient = −2.32 [95% CI = −4.04; −0.59]). Poor rhinitis control, measured by the combined symptom-medication score, was associated with worse VAS education (regression coefficient = 0.88 [95% CI = 0.88; 0.92]), higher impact on academic productivity (regression coefficient = 0.69 [95% CI = 0.49; 0.90]), and higher percentage of missed education hours due to allergy (regression coefficient = 0.44 [95% CI = 0.25; 0.63]).Conclusion: Allergy symptoms and worse rhinitis control are associated with worse academic productivity, whereas immunotherapy is associated with higher productivity.

AB - Background: Several studies have suggested an impact of allergic rhinitis on academic productivity. However, large studies with real-world data (RWD) are not available.Objective: To use RWD to assess the impact of allergic rhinitis on academic performance (measured through a visual analog scale [VAS] education and the Work Productivity and Activity Impairment Questionnaire plus Classroom Impairment Questions: Allergy Specific [WPAI+CIQ:AS] questionnaire), and to identify factors associated with the impact of allergic rhinitis on academic performance.Methods: We assessed data from the MASK-air mHealth app of users aged 13 to 29 years with allergic rhinitis. We assessed the correlation between variables measuring the impact of allergies on academic performance (VAS education, WPAI+CIQ:AS impact of allergy symptoms on academic performance, and WPAI+CIQ:AS percentage of education hours lost due to allergies) and other variables. In addition, we identified factors associated with the impact of allergic symptoms on academic productivity through multivariable mixed models.Results: A total of 13,454 days (from 1970 patients) were studied. VAS education was strongly correlated with the WPAI+CIQ:AS impact of allergy symptoms on academic productivity (Spearman correlation coefficient = 0.71 [95% confidence interval (CI) = 0.58; 0.80]), VAS global allergy symptoms (0.70 [95% CI = 0.68; 0.71]), and VAS nose (0.66 [95% CI = 0.65; 0.68]). In multivariable regression models, immunotherapy showed a strong negative association with VAS education (regression coefficient = −2.32 [95% CI = −4.04; −0.59]). Poor rhinitis control, measured by the combined symptom-medication score, was associated with worse VAS education (regression coefficient = 0.88 [95% CI = 0.88; 0.92]), higher impact on academic productivity (regression coefficient = 0.69 [95% CI = 0.49; 0.90]), and higher percentage of missed education hours due to allergy (regression coefficient = 0.44 [95% CI = 0.25; 0.63]).Conclusion: Allergy symptoms and worse rhinitis control are associated with worse academic productivity, whereas immunotherapy is associated with higher productivity.

KW - Allergic rhinitis

KW - MASK

KW - Real-world data

KW - Mobile health

KW - Academic productivity

UR - http://www.scopus.com/inward/record.url?scp=85138100696&partnerID=8YFLogxK

U2 - 10.1016/j.jaip.2022.08.015

DO - 10.1016/j.jaip.2022.08.015

M3 - Article

C2 - 35998876

SN - 2213-2198

VL - 10

SP - 3008-3017.e4

JO - Journal of Allergy and Clinical Immunology: In Practice

JF - Journal of Allergy and Clinical Immunology: In Practice

IS - 11

ER -

Academic productivity of young people with allergic rhinitis: a MASK-air study

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