Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model

Liviu-Gabriel Bodea, Harrison Tudor Evans, Ann Van der Jeugd, Lars M. Ittner, Fabien Delerue, Jillian Kril, Glenda Halliday, John Hodges, Mathew C. Kiernan, Jürgen Götz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
24 Downloads (Pure)

Abstract

Age is a critical factor in the prevalence of tauopathies, including Alzheimer's disease. To observe how an aging phenotype interacts with and affects the pathological intracellular accumulation of hyperphosphorylated tau, the tauopathy mouse model pR5 (expressing P301L mutant human tau) was back-crossed more than ten times onto a senescence-accelerated SAMP8 background to establish the new strain, SApT. Unlike SAMP8 mice, pR5 mice are characterized by a robust tau pathology particularly in the amygdala and hippocampus. Analysis of age-matched SApT mice revealed that pathological tau phosphorylation was increased in these brain regions compared to those in the parental pR5 strain. Moreover, as revealed by immunohistochemistry, phosphorylation of critical tau phospho-epitopes (P-Ser202/P-Ser205 and P-Ser235) was significantly increased in the amygdala of SApT mice in an age-dependent manner, suggesting an age-associated effect of tau phosphorylation. Anxiety tests revealed that the older cohort of SApT mice (10 months vs. 8 months) exhibited a behavioural pattern similar to that observed for age-matched tau transgenic pR5 mice and not the SAMP8 parental mice. Learning and memory, however, appeared to be governed by the accelerated aging background of the SAMP8 strain, as at both ages investigated, SAMP8 and SApT mice showed a decreased learning capacity compared to pR5 mice. We therefore conclude that accelerated aging exacerbates pathological tau phosphorylation, leading to changes in normal behaviour. These findings further suggest that SApT mice may be a useful novel model in which to study the role of a complex geriatric phenotype in tauopathy.

Original languageEnglish
Pages (from-to)377-386
Number of pages10
JournalAging Cell
Volume16
Issue number2
DOIs
Publication statusPublished - 1 Apr 2017
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
A corrigendum exists for this article and can be found in Aging Cell (2018) Vol 17(1) p. e12712 at doi: 10.1111/acel.12712

Keywords

  • aging
  • frontotemporal dementia
  • geriatric condition
  • senescence
  • tau
  • transgenic

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