Accelerated em reconstruction in total-body PET: Potential for improving tumour detectability

S. R. Meikle*, B. F. Hutton, D. L. Bailey, P. K. Hooper, M. J. Fulham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


Total-body positron emission tomography (PET) is a useful diagnostic tool for evaluating malignant disease. However, tumour detection is limited by image artefacts due to the lack of attenuation correction and noise. Attenuation correction may be possible using transmission data acquired after or simultaneously with emission data. Despite the elimination of attenuation artefacts, however, tumour detection is still hampered by noise, which is amplified during image reconstruction by filtered backprojection (FBP). The authors have investigated, as an alternative to FBP, an accelerated expectation maximization (EM) algorithm for its potential to improve tumour detectability in total-body PET. Signal to noise ratio (SNR), calculated for a tumour with respect to the surrounding background, is used as a figure of merit. A software tumour phantom, with conditions typical of those encountered in a total-body PET study using simultaneous acquisition, is used to optimize and compare various reconstruction approaches. Accelerated EM reconstruction followed by two-dimensional filtering is shown to yield significantly higher SNR than FBP for a range of tumour sizes, concentrations and counting statistics ( Delta SNR=6.3+or-3.9, p<0.001). The methods developed are illustrated by examples derived from physical phantom and patient data.

Original languageEnglish
Article number012
Pages (from-to)1689-1704
Number of pages16
JournalPhysics in Medicine and Biology
Issue number10
Publication statusPublished - 1994
Externally publishedYes


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