Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Sicong Tu, Laurie Miller, Olivier Piguet, Michael Hornberger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.

Original languageEnglish
Article number320
Pages (from-to)1-9
Number of pages9
JournalFrontiers in Behavioral Neuroscience
Volume8
Issue numberSEP
DOIs
Publication statusPublished - 15 Sep 2014
Externally publishedYes

Keywords

  • Anterograde memory
  • Mammillothalamic tract
  • MRI
  • Stroke
  • Thalamus

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