Accelerating the search for the missing proteins in the human proteome

Mark S. Baker, Seong Beom Ahn, Abidali Mohamedali, Mohammad T. Islam, David Cantor, Peter D. Verhaert, Susan Fanayan, Samridhi Sharma, Edouard C. Nice, Mark Connor*, Shoba Ranganathan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

79 Citations (Scopus)
77 Downloads (Pure)


The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, similar to 18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

Original languageEnglish
Article number14271
Pages (from-to)1-13
Number of pages13
JournalNature Communications
Publication statusPublished - 24 Jan 2017

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Mass spectrometry
  • Proteome
  • Proteomics


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