Accelerating the search for the missing proteins in the human proteome

Mark S. Baker; Seong Beom Ahn; Abidali Mohamedali; Mohammad T. Islam; David Cantor; Peter D. Verhaert; Susan Fanayan; Samridhi Sharma; Edouard C. Nice; Mark Connor; Shoba Ranganathan

doi:10.1038/ncomms14271

Accelerating the search for the missing proteins in the human proteome

Mark S. Baker, Seong Beom Ahn, Abidali Mohamedali, Mohammad T. Islam, David Cantor, Peter D. Verhaert, Susan Fanayan, Samridhi Sharma, Edouard C. Nice, Mark Connor^*, Shoba Ranganathan

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Review article › peer-review

89 Citations (Scopus)

129 Downloads (Pure)

Abstract

The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, similar to 18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

Original language	English
Article number	14271
Pages (from-to)	1-13
Number of pages	13
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms14271
Publication status	Published - 24 Jan 2017

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Mass spectrometry
Proteome
Proteomics

Access to Document

10.1038/ncomms14271

Publisher version (open access)Final published version, 1.72 MBLicence: CC BY

Cite this

@article{866f22b9bc4542a2a92f9b8fad9792bd,

title = "Accelerating the search for the missing proteins in the human proteome",

abstract = "The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, similar to 18\% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.",

keywords = "Mass spectrometry, Proteome, Proteomics",

author = "Baker, \{Mark S.\} and Ahn, \{Seong Beom\} and Abidali Mohamedali and Islam, \{Mohammad T.\} and David Cantor and Verhaert, \{Peter D.\} and Susan Fanayan and Samridhi Sharma and Nice, \{Edouard C.\} and Mark Connor and Shoba Ranganathan",

note = "Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2017",

month = jan,

day = "24",

doi = "10.1038/ncomms14271",

language = "English",

volume = "8",

pages = "1--13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Springer, Springer Nature",

}

TY - JOUR

T1 - Accelerating the search for the missing proteins in the human proteome

AU - Baker, Mark S.

AU - Ahn, Seong Beom

AU - Mohamedali, Abidali

AU - Islam, Mohammad T.

AU - Cantor, David

AU - Verhaert, Peter D.

AU - Fanayan, Susan

AU - Sharma, Samridhi

AU - Nice, Edouard C.

AU - Connor, Mark

AU - Ranganathan, Shoba

N1 - Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2017/1/24

Y1 - 2017/1/24

N2 - The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, similar to 18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

AB - The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, similar to 18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins.

KW - Mass spectrometry

KW - Proteome

KW - Proteomics

UR - https://www.scopus.com/pages/publications/85010991380

U2 - 10.1038/ncomms14271

DO - 10.1038/ncomms14271

M3 - Review article

C2 - 28117396

AN - SCOPUS:85010991380

SN - 2041-1723

VL - 8

SP - 1

EP - 13

JO - Nature Communications

JF - Nature Communications

M1 - 14271

ER -

Accelerating the search for the missing proteins in the human proteome

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this