Activation of NK cells by ADCC antibodies and HIV disease progression

Amy W. Chung, Marjon Navis, Gamze Isitman, Leia Wren, Julie Silvers, Janaki Amin, Stephen J. Kent*, Ivan Stratov

*Corresponding author for this work

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Antibody-dependent cellular cytotoxicity (ADCC) is of considerable interest as an immune response that may facilitate the control of HIV infection. We studied ADCC responses prospectively in a cohort of 79 HIV-positive subjects followed up for a mean of 2.3 years without antiretroviral therapy. We used a novel assay of the ability of ADCC to activate natural killer (NK) cells, either from the same HIV-positive subject or from a healthy blood donor. We found that ADCC responses to either gp140 Env protein or HIV peptide pools were common in HIV-positive subjects when NK cells from the HIV-positive subject were used but did not correlate with markers of HIV disease progression. In contrast, ADCC responses to whole gp140 Env protein were strongly associated with a slower decline in CD4 T-cell loss when healthy donor NK cells were used as effectors. Our data had implications for induction of the most effective ADCC responses by HIV vaccines.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume58
Issue number2
DOIs
Publication statusPublished - 1 Oct 2011
Externally publishedYes

Keywords

  • ADCC
  • CD4 T cells
  • HIV
  • NK Cells
  • viral load

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