Active template synthesis of rotaxanes and molecular shuttles with switchable dynamics by four-component PdII-promoted Michael additions

Stephen M. Goldup, David A. Leigh, Paul J. Lusby, Roy T. McBurney, Alexandra M Z Slawin

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(Chemical Equation). Taking the Michael: Rotaxanes (see structure) and molecular shuttles are prepared in up to 99% yield by successive Pd II-promoted 1,4-conjugate additions in a one-pot four-component assembly process. This process represents the first active template reaction in which the template motif is retained in the interlocked product.

Original languageEnglish
Pages (from-to)3381-3384
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number18
Publication statusPublished - 21 Apr 2008
Externally publishedYes



  • Lewis acid catalysts
  • Molecular shuttles
  • Palladium
  • Rotaxanes
  • Template synthesis

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