Acute activation and inhibition of the sympathetic baroreceptor reflex

Melissa M J Farnham*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Many laboratories around the world use baroreceptor denervation in their investigations of the cardiovascular system. The most common method, performed in the rat, is a permanent denervation where the carotid sinus and aortic depressor nerves are transected. Here, we describe detailed step-by-step methods for acute reversible baroreceptor denervation in the rat. In this method, local anaesthetic agents are superfused around the region of the carotid sinus. With this method, complete baroreceptor denervation can be achieved for longer (bupivacaine, 30-60 min) or shorter (lignocaine, 10-30 min) periods, without harming the physiological state of the rat.

    Original languageEnglish
    Title of host publicationStimulation and Inhibition of Neurons
    Pages47-58
    Number of pages12
    Volume78
    DOIs
    Publication statusPublished - 2013

    Publication series

    NameNeuromethods
    Volume78
    ISSN (Print)08932336
    ISSN (Electronic)19406045

    Keywords

    • Barodenervation
    • Bupivacaine
    • Carotid sinus
    • Lignocaine

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  • Cite this

    Farnham, M. M. J. (2013). Acute activation and inhibition of the sympathetic baroreceptor reflex. In Stimulation and Inhibition of Neurons (Vol. 78, pp. 47-58). (Neuromethods; Vol. 78). https://doi.org/10.1007/978-1-62703-233-9-4