TY - CHAP
T1 - Acute activation and inhibition of the sympathetic baroreceptor reflex
AU - Farnham, Melissa M J
PY - 2013
Y1 - 2013
N2 - Many laboratories around the world use baroreceptor denervation in their investigations of the cardiovascular system. The most common method, performed in the rat, is a permanent denervation where the carotid sinus and aortic depressor nerves are transected. Here, we describe detailed step-by-step methods for acute reversible baroreceptor denervation in the rat. In this method, local anaesthetic agents are superfused around the region of the carotid sinus. With this method, complete baroreceptor denervation can be achieved for longer (bupivacaine, 30-60 min) or shorter (lignocaine, 10-30 min) periods, without harming the physiological state of the rat.
AB - Many laboratories around the world use baroreceptor denervation in their investigations of the cardiovascular system. The most common method, performed in the rat, is a permanent denervation where the carotid sinus and aortic depressor nerves are transected. Here, we describe detailed step-by-step methods for acute reversible baroreceptor denervation in the rat. In this method, local anaesthetic agents are superfused around the region of the carotid sinus. With this method, complete baroreceptor denervation can be achieved for longer (bupivacaine, 30-60 min) or shorter (lignocaine, 10-30 min) periods, without harming the physiological state of the rat.
KW - Barodenervation
KW - Bupivacaine
KW - Carotid sinus
KW - Lignocaine
UR - http://www.scopus.com/inward/record.url?scp=84871830191&partnerID=8YFLogxK
U2 - 10.1007/978-1-62703-233-9-4
DO - 10.1007/978-1-62703-233-9-4
M3 - Chapter
AN - SCOPUS:84871830191
SN - 9781627032322
VL - 78
T3 - Neuromethods
SP - 47
EP - 58
BT - Stimulation and Inhibition of Neurons
ER -