Acute distal intestinal obstruction in gnotobiotic rats - Intestinal morphology and cell renewal

R. Ecknauer*, R. M. Clarke, H. Meyer

*Corresponding author for this work

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1. Complete mechanical obstruction of the distal small intestine was produced in gnotobiotic rats. 72 h after the operation small intestinal morphology and epithelial cell renewal were investigated proximal and distal to the site of obstruction. 2. Proximal to the site of obstruction there were minor changes in villus height, base length and in villus cell number, a large increase in depth and diameter of the crypts and an approximately threefold increase in cell renewal. 3. Distal to the site of obstruction there were no differences between the intestines of rats with obstruction and controls. 4. The apparent lack of secretion by the goblet cells and the reduced number of intraepithelial leucocytes suggest that the barrier function of the small intestine is impaired in obstruction.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalVirchows Archiv B Cell Pathology
Issue number1
Publication statusPublished - Dec 1977



  • Bacterial overgrowth
  • Cell division
  • Intestinal mucosa
  • Intestinal obstruction

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