TY - JOUR
T1 - Acute psychiatric illness in a young woman
T2 - an unusual form of encephalitis
AU - Parratt, Kaitlyn L.
AU - Allan, Martin
AU - Lewis, Simon J. G.
AU - Dalmau, Josep
AU - Halmagyi, Gabor M.
AU - Spies, Judith M.
PY - 2009/9/7
Y1 - 2009/9/7
N2 - A 21-year-old woman was admitted to hospital with a diagnosis of acute psychotic mania, but developed, over approximately 6 weeks, seizures, delirium, catatonia, movement disorder and autonomic dysfunction. She was found to have antibodies to N-methyl-D-aspartate (NMDA) NR1-NR2 receptors in both serum and cerebrospinal fluid, consistent with anti-NMDA-receptor encephalitis, a severe, potentially lethal but treatment-responsive encephalitis often associated with ovarian tumour. With aggressive immunotherapy and bilateral oophorectomy, she recovered over a period of 14 months from her initial presentation. No ovarian tumour was identified.
AB - A 21-year-old woman was admitted to hospital with a diagnosis of acute psychotic mania, but developed, over approximately 6 weeks, seizures, delirium, catatonia, movement disorder and autonomic dysfunction. She was found to have antibodies to N-methyl-D-aspartate (NMDA) NR1-NR2 receptors in both serum and cerebrospinal fluid, consistent with anti-NMDA-receptor encephalitis, a severe, potentially lethal but treatment-responsive encephalitis often associated with ovarian tumour. With aggressive immunotherapy and bilateral oophorectomy, she recovered over a period of 14 months from her initial presentation. No ovarian tumour was identified.
UR - http://www.scopus.com/inward/record.url?scp=77950297284&partnerID=8YFLogxK
U2 - 10.5694/j.1326-5377.2009.tb02787.x
DO - 10.5694/j.1326-5377.2009.tb02787.x
M3 - Article
C2 - 19740054
AN - SCOPUS:77950297284
SN - 0025-729X
VL - 191
SP - 284
EP - 286
JO - Medical Journal of Australia
JF - Medical Journal of Australia
IS - 5
ER -