Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues

Lars M. Ittner*, Matthias Klugmann, Yazi D. Ke

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that presents with cognitive decline. The current understanding of underlying disease mechanisms remains incomplete. Genetically modified mouse models have been instrumental in deciphering pathomechanisms in AD. While these models were typically generated by classical transgenesis and genome editing, the use of adeno-associated viruses (AAVs) to model and investigate AD in mice, as well as to develop novel gene-therapy approaches, is emerging. Here, we reviewed literature that used AAVs to study and model AD and discuss potential gene therapy strategies.

Original languageEnglish
Pages (from-to)3649-3665
Number of pages17
JournalBritish Journal of Pharmacology
Volume176
Issue number18
Early online date28 Feb 2019
DOIs
Publication statusPublished - 1 Sep 2019

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