Adenosine-anchored triphosphate subsite probing

Distinguishing between HER-2 and HER-4 tyrosine protein kinases

Fei Liu, Eric F. Johnson, David J. Austin*, Karen S. Anderson

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family. The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.

Original languageEnglish
Pages (from-to)3587-3592
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number20
DOIs
Publication statusPublished - 20 Oct 2003
Externally publishedYes

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