Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Bart A. Eijkelkamp, Uwe H. Stroeher, Karl A. Hassan, Michael S. Papadimitrious, Ian T. Paulsen, Melissa H. Brown*

*Corresponding author for this work

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalFEMS Microbiology Letters
Volume323
Issue number1
DOIs
Publication statusPublished - Oct 2011

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