Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Bart A. Eijkelkamp; Uwe H. Stroeher; Karl A. Hassan; Michael S. Papadimitrious; Ian T. Paulsen; Melissa H. Brown

doi:10.1111/j.1574-6968.2011.02362.x

Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Bart A. Eijkelkamp, Uwe H. Stroeher, Karl A. Hassan, Michael S. Papadimitrious, Ian T. Paulsen, Melissa H. Brown^*

^*Corresponding author for this work

Macquarie University BioFocus Research Centre

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

Original language	English
Pages (from-to)	44-51
Number of pages	8
Journal	FEMS Microbiology Letters
Volume	323
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2011.02362.x
Publication status	Published - Oct 2011

Access to Document

10.1111/j.1574-6968.2011.02362.x

Cite this

@article{bb8a6628f46948c097160ee0fe9db3f2,

title = "Adherence and motility characteristics of clinical Acinetobacter baumannii isolates",

abstract = "Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.",

author = "Eijkelkamp, {Bart A.} and Stroeher, {Uwe H.} and Hassan, {Karl A.} and Papadimitrious, {Michael S.} and Paulsen, {Ian T.} and Brown, {Melissa H.}",

year = "2011",

month = oct,

doi = "10.1111/j.1574-6968.2011.02362.x",

language = "English",

volume = "323",

pages = "44--51",

journal = "FEMS Microbiology Letters",

issn = "0378-1097",

publisher = "Blackwell Publishing",

number = "1",

}

TY - JOUR

T1 - Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

AU - Eijkelkamp, Bart A.

AU - Stroeher, Uwe H.

AU - Hassan, Karl A.

AU - Papadimitrious, Michael S.

AU - Paulsen, Ian T.

AU - Brown, Melissa H.

PY - 2011/10

Y1 - 2011/10

N2 - Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

AB - Acinetobacter baumannii continues to be a major health problem especially in hospital settings. Herein, features that may play a role in persistence and disease potential were investigated in a collection of clinical A. baumannii strains from Australia. Twitching motility was found to be a common trait in A. baumannii international clone I strains and in abundant biofilm formers, whereas swarming motility was only observed in isolates not classified within the international clone lineages. Bioinformatic analysis of the type IV fimbriae revealed a correlation between PilA sequence homology and motility. A high level of variability in adherence to both abiotic surfaces and epithelial cells was found. We report for the first time the motility characteristics of a large number of A. baumannii isolates and present a direct comparison of A. baumannii binding to nasopharyngeal and lung epithelial cells.

UR - http://www.scopus.com/inward/record.url?scp=80052744647&partnerID=8YFLogxK

U2 - 10.1111/j.1574-6968.2011.02362.x

DO - 10.1111/j.1574-6968.2011.02362.x

M3 - Article

C2 - 22092679

AN - SCOPUS:80052744647

SN - 0378-1097

VL - 323

SP - 44

EP - 51

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 1

ER -

Adherence and motility characteristics of clinical Acinetobacter baumannii isolates

Abstract

Access to Document

Other files and links

Fingerprint

Cite this