Advances in structural and molecular neuroimaging in Alzheimer's disease

Kathryn A. Ellis, Christopher C. Rowe, Cassandra E I Szoeke, Victor L. Villemagne, David Ames, Gaël Chételat, Ralph N. Martins, Colin L. Masters, Jurgen Fripp, Oscar Acosta, Parnesh Raniga, Pierrick T. Bourgeat, Olivier Salvado*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

• Longer life expectancies lead to increases in the prevalence of age-associated illnesses. The number of Australians with dementia is predicted to rise, from 234 000 in 2009 to over 1 million by 2050, as a result of the increased prevalence of Alzheimer's disease (AD), the leading cause of dementia in the elderly.

• Early diagnosis of AD will become more important as diseasemodifying therapies emerge within the next decade.

• Advances in molecular neuroimaging with amyloid-β-specific radioligands for positron emission tomography, aided by magnetic resonance imaging techniques, allow detection of AD years before symptoms of dementia develop.

• Longitudinal prospective studies, such as the Australian Imaging Biomarkers and Lifestyle (AIBL) study of ageing, will determine the sensitivity and specificity of these analysis techniques for diagnosing AD and predicting cognitive decline.

Original languageEnglish
Pages (from-to)S20-S23
Number of pages4
JournalMedical Journal of Australia
Volume194
Issue number4
Publication statusPublished - Feb 2011
Externally publishedYes

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