Advances in the management of organophosphate poisoning

John Victor Peter*, John L. Moran, Petra L. Graham

*Corresponding author for this work

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Organophosphate (OP) poisoning is commonly encountered in agricultural communities. The mainstay of therapy in OP poisoning is the use of atropine. However, several other therapies have been evaluated. Although oxime has been the most studied antidote, results in humans have been disappointing and limited by the lack of well-designed, prospective, randomised controlled trials. The key factor in determining outcomes in OP poisoning appears to be the timing of antidote administration. Other adjuvants, such as magnesium, fresh frozen plasma and haemoperfusion appear promising, and need to be explored further. A multi-faceted approach may be the answer to improving outcomes in OP poisoning. This review evaluates the advances in OP management over the last 20 year.

Original languageEnglish
Pages (from-to)1451-1464
Number of pages14
JournalExpert Opinion on Pharmacotherapy
Volume8
Issue number10
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • Haemoperfusion
  • Insecticide
  • Meta-analysis
  • Oxime
  • Random effects

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