Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment

Narayana Subramaniam; Samskruthi Murthy; Deepak Balasubramanian; Tsu-Hui (Hubert) Low; Sivakumar Vidhyadharan; Jonathan R. Clark; Krishnakumar Thankappan; Subramania Iyer

doi:10.1002/hed.25168

Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment

Narayana Subramaniam, Samskruthi Murthy, Deepak Balasubramanian, Tsu-Hui (Hubert) Low, Sivakumar Vidhyadharan, Jonathan R. Clark, Krishnakumar Thankappan, Subramania Iyer

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Background: The American Joint Committee on Cancer (AJCC) eighth edition has incorporated depth of invasion into TNM classification of oral cavity squamous cell carcinoma (SCC) due to the prognostic impact on recurrence and survival. After reclassifying our patients with T1 to T2 oral cavity SCC according to these recommendations, we intended to study the effect of adverse pathological features (perineural invasion [PNI], lymphovascular invasion, and differentiation) on overall survival (OS).

Methods: We conducted a retrospective analysis of 442 patients with T1 to T2 oral cavity SCC. Univariate and multivariate analysis was performed for impact of adverse pathological features on OS.

Results: For the newly reclassified T1 to T2 oral cavity tumors, on multivariate analysis, the prognostically relevant parameters were PNI (P = .032) and differentiation (P = .009). Increasing adverse pathological features resulted in worse survival (P = .005).

Conclusion: Incorporation of PNI and differentiation better reflect prognostic outcome in oral cavity tumors classified as T1 to T2 as per the new AJCC eighth edition. Increasing adverse pathological features resulted in worse survival.

Original language	English
Pages (from-to)	2123-2128
Number of pages	6
Journal	Head and Neck
Volume	40
Issue number	10
DOIs	https://doi.org/10.1002/hed.25168
Publication status	Published - Oct 2018
Externally published	Yes

Keywords

adverse pathological features
American Joint Committee on Cancer (AJCC) eighth edition
differentiation
oral squamous cell carcinoma
perineural invasion

Access to Document

10.1002/hed.25168

Cite this

@article{dd2029d6adac4cfb966954088a05ae0f,

title = "Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment",

abstract = "Background: The American Joint Committee on Cancer (AJCC) eighth edition has incorporated depth of invasion into TNM classification of oral cavity squamous cell carcinoma (SCC) due to the prognostic impact on recurrence and survival. After reclassifying our patients with T1 to T2 oral cavity SCC according to these recommendations, we intended to study the effect of adverse pathological features (perineural invasion [PNI], lymphovascular invasion, and differentiation) on overall survival (OS). Methods: We conducted a retrospective analysis of 442 patients with T1 to T2 oral cavity SCC. Univariate and multivariate analysis was performed for impact of adverse pathological features on OS. Results: For the newly reclassified T1 to T2 oral cavity tumors, on multivariate analysis, the prognostically relevant parameters were PNI (P = .032) and differentiation (P = .009). Increasing adverse pathological features resulted in worse survival (P = .005). Conclusion: Incorporation of PNI and differentiation better reflect prognostic outcome in oral cavity tumors classified as T1 to T2 as per the new AJCC eighth edition. Increasing adverse pathological features resulted in worse survival.",

keywords = "adverse pathological features, American Joint Committee on Cancer (AJCC) eighth edition, differentiation, oral squamous cell carcinoma, perineural invasion",

author = "Narayana Subramaniam and Samskruthi Murthy and Deepak Balasubramanian and Low, {Tsu-Hui (Hubert)} and Sivakumar Vidhyadharan and Clark, {Jonathan R.} and Krishnakumar Thankappan and Subramania Iyer",

year = "2018",

month = oct,

doi = "10.1002/hed.25168",

language = "English",

volume = "40",

pages = "2123--2128",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons",

number = "10",

}

TY - JOUR

T1 - Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment

AU - Subramaniam, Narayana

AU - Murthy, Samskruthi

AU - Balasubramanian, Deepak

AU - Low, Tsu-Hui (Hubert)

AU - Vidhyadharan, Sivakumar

AU - Clark, Jonathan R.

AU - Thankappan, Krishnakumar

AU - Iyer, Subramania

PY - 2018/10

Y1 - 2018/10

N2 - Background: The American Joint Committee on Cancer (AJCC) eighth edition has incorporated depth of invasion into TNM classification of oral cavity squamous cell carcinoma (SCC) due to the prognostic impact on recurrence and survival. After reclassifying our patients with T1 to T2 oral cavity SCC according to these recommendations, we intended to study the effect of adverse pathological features (perineural invasion [PNI], lymphovascular invasion, and differentiation) on overall survival (OS). Methods: We conducted a retrospective analysis of 442 patients with T1 to T2 oral cavity SCC. Univariate and multivariate analysis was performed for impact of adverse pathological features on OS. Results: For the newly reclassified T1 to T2 oral cavity tumors, on multivariate analysis, the prognostically relevant parameters were PNI (P = .032) and differentiation (P = .009). Increasing adverse pathological features resulted in worse survival (P = .005). Conclusion: Incorporation of PNI and differentiation better reflect prognostic outcome in oral cavity tumors classified as T1 to T2 as per the new AJCC eighth edition. Increasing adverse pathological features resulted in worse survival.

AB - Background: The American Joint Committee on Cancer (AJCC) eighth edition has incorporated depth of invasion into TNM classification of oral cavity squamous cell carcinoma (SCC) due to the prognostic impact on recurrence and survival. After reclassifying our patients with T1 to T2 oral cavity SCC according to these recommendations, we intended to study the effect of adverse pathological features (perineural invasion [PNI], lymphovascular invasion, and differentiation) on overall survival (OS). Methods: We conducted a retrospective analysis of 442 patients with T1 to T2 oral cavity SCC. Univariate and multivariate analysis was performed for impact of adverse pathological features on OS. Results: For the newly reclassified T1 to T2 oral cavity tumors, on multivariate analysis, the prognostically relevant parameters were PNI (P = .032) and differentiation (P = .009). Increasing adverse pathological features resulted in worse survival (P = .005). Conclusion: Incorporation of PNI and differentiation better reflect prognostic outcome in oral cavity tumors classified as T1 to T2 as per the new AJCC eighth edition. Increasing adverse pathological features resulted in worse survival.

KW - adverse pathological features

KW - American Joint Committee on Cancer (AJCC) eighth edition

KW - differentiation

KW - oral squamous cell carcinoma

KW - perineural invasion

UR - http://www.scopus.com/inward/record.url?scp=85052388266&partnerID=8YFLogxK

U2 - 10.1002/hed.25168

DO - 10.1002/hed.25168

M3 - Article

C2 - 30102804

SN - 1043-3074

VL - 40

SP - 2123

EP - 2128

JO - Head and Neck

JF - Head and Neck

IS - 10

ER -

Adverse pathologic features in T1/2 oral squamous cell carcinoma classified by the American Joint Committee on Cancer eighth edition and implications for treatment

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this