Aerosol particle generation from solution-based pressurized metered dose inhalers: a technical overview of parameters that influence respiratory deposition

Bing Zhu, Daniela Traini, Paul Young*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

There are a multitude of formulation factors to consider when developing a solution-based pressurized metered dose inhaler (pMDI). Evaluation of these variables and their underpinning driving force has been performed over the years. Key components, including formulation composition and device design, play significant roles in determining the aerosol performance of these solution-based formulations. This review outlines research efforts that have focused on these essential governing factors, how the aerosol performance changes when these variables are modified and fundamental mechanisms affecting the delivery efficiency of such formulations.

Original languageEnglish
Pages (from-to)897-910
Number of pages14
JournalPharmaceutical Development and Technology
Volume20
Issue number8
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Aerosol performance
  • Device variables
  • Formulation variables
  • Particle formation
  • Solution-based pMDI

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