Abstract
There are a multitude of formulation factors to consider when developing a solution-based pressurized metered dose inhaler (pMDI). Evaluation of these variables and their underpinning driving force has been performed over the years. Key components, including formulation composition and device design, play significant roles in determining the aerosol performance of these solution-based formulations. This review outlines research efforts that have focused on these essential governing factors, how the aerosol performance changes when these variables are modified and fundamental mechanisms affecting the delivery efficiency of such formulations.
Original language | English |
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Pages (from-to) | 897-910 |
Number of pages | 14 |
Journal | Pharmaceutical Development and Technology |
Volume | 20 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Jan 2015 |
Externally published | Yes |
Keywords
- Aerosol performance
- Device variables
- Formulation variables
- Particle formation
- Solution-based pMDI